白细胞去除及其临床应用进展_赵树铭.pdfVIP

·478 · 中国实验血液学杂志　Journal of Experimental Hematology 2002;10(5):478-482 赵树铭,林武存, 刘景汉1 1 (第三军医大学附属西南医院输血科,重庆400038;中国人民解放军总医院输血科, 北京100039) 　　输血可因输入同种异体血液及其制剂而导致白细胞介导的输血 应及输血相关病毒的传播。 去除血液 及其制剂中白细胞则可有效地减低免疫抑制效应及传播病毒的危险。成分血液因制备时采用白膜法, 通常可去除 全血中2/3 的白细胞。采用白细胞专用滤器, 则可去除血液中99.9%的白细胞, 可以明显减少白细胞介导的输血 应, 如非溶血性发热性输血 应和移植物抗宿主病。白细胞去除可减少输血传播病毒的危险。 另外, 白细胞去 除对治疗心外科病人因白细胞介导的炎症和器官再灌注损伤、溃疡性结肠炎以及一些自身免疫性和神经性疾病等 均有重要作用。 　　白细胞去除;输血;输血 应 　　R457.1;R331.142 Leucocyte Removal and Its Clinical Application 1 ZHAO Shu-M ing, LIN Wu-Cun, LIU Jing-Han (Department of B lood Transf usion, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China; 1Department of Blood Transf usion, The General Hospital of P A, Beij ing 100039, China) Abstract　　Bl d transfusi n leads t leuc cyte-mediated adverse reacti ns related t the transfusi n f leuc cytes in all geneic bl d and bl d pr ducts.The leuc cytes are als capable f transmitting virus infecti n.Leuc cyte depleti n f h m l g us bl d pr ducts can effectively reduce the immun suppressive effect as well as minimize the likelih d f transmitting virus.Bl d c mp nent transfusi n is generally “buffy-c at-p r”, w hich rem ves ab ut tw thirds f the leuc cytes present in w h le bl d.Using special filters, bl d c mp nent can be filtrated 99.9% f the leuc cytes. Leuc cyte-depleti n using filter sh uld significantly lessen the leuc cyte-mediated transfusi n adverse reacti ns, such as febrile n n-hem lytic transfusi n reacti ns and graft versus h st disease.At the same time, leuc cyte filtrati n can decrease the risk f transmitting virus.Otherwise, leuc cyte-depleti n plays very imp rtant r le in the treatment f cardiac surgical patients t attenuate leuk cyte-mediated inflammati n and rgan reperfusi n injur