(DLB) 额颞叶痴呆.PPT

Left) Structural healthy brain networks were obtained from diffusion MRI scans of 14 young healthy volunteers, followed by whole brain tractography. The nodes of this network correspond to cortical and subcortical gray matter regions obtained from a labeled T1-weighted brain atlas, and the edges of this network are proportional to the number and strength of the ?ber tracts that connect the nodes. Proposed network diffusion model and its eigenmodes are derived from this healthy network. The ?rst three eigenmodes, which we have hypothesized to be predictive of dementia atrophy patterns, are then tabulated and plotted. (Right) We then compare the predicted patterns with measured atrophy of dementia patients (AD, bvFTD, and age-matched normal subjects), obtained via a completely separate processing pipeline, available in the SPM Matlab toolbox. T1-weighted images of each subject were coregistered with the same atlas as in the left panel, and graymatter regions were parcellated using the prelabeled atlas information. Volume of each cortical and subcortical gray- matter region was measured. The atrophy of each region was obtained in terms of a t-statistic between the diseased and age-matched normal groups. Finally, the predicted and measured atrophy patterns were statistically compared using correlation analysis. * 这些标记物支持AD诊断，但鉴别AD与其他痴呆诊断时特异性低（39 – 90%），这可能与合并AD病理改变有关 目前尚缺乏统一的检测和样本处理方法 血管炎、感染或脱髓鞘疾病 * 1984年基础上修改后的2007年版本，目前是比较通用的经典的诊断标准，示踪剂选用18F-FDDNP是一种脂溶性小分子化合物．能够快速通过血脑屏障，可染色AD患者脑中的老年斑和神经原纤维缠结 * 2011年美国阿尔茨海默病协会和衰老研究所进行了一个重新修订的痴呆诊断标准，其中临床很可能的AD诊断标准如下： * 1 (A) Diff usion-weighted image of an acute small deep (lacunar) infarct (arrow): less than 2 cm diameter, hyperintense on diff usion imaging, FLAIR, and T2-weighted imaging, hypointense on T1-weighted imaging. (B) Lacune on FLAIR imaging: a CSF-containing cavity, more than 3 mm and less than 1·5 cm diameter, in white or deep grey matter or brainstem, signal characteristics of CSF on o