基于复杂网络可视化的癫痫患者大脑状态研究.pdf

RESEARCH WORK 研究论著 基于复杂网络可视化的癫痫患者大脑状 态研究 Investigation of Epilepsy Patients’ Brains Based on Complex Network Visualization 1,2 3 1 [摘 要] 癫痫是一种伴随短暂认知损伤的大脑疾病，由于病理机制的异质性，导致其缺乏临床诊断 何艳 ，于云莉 ，杨帆 1.贵州医科大学 生物与工程学院， 和治疗评价的客观度量。多通道脑电记录是检测大脑状态的重要手段。本文采用复杂网络可视化 贵州 贵阳 550004 ；2. 西安交通大 的方法对癫痫患者大脑功能状态进行研究，利用相位锁定值方法从癫痫患者的静息态皮层脑电图 学 生命科学与技术学院，陕西 西安 （EEG ）信号中提取出加权频率依赖的复杂网络，使用Pajek软件和最小生成树算法对癫痫患者大 710049 ；3.贵州医科大学附属医院 神 脑的复杂网络进行描述，可为量化大脑特征提供系统化、全局化的可视化思路，未来可以为进一 经内科，贵州贵阳 550004 步辅助诊断提供技术支持。 [关键词] 复杂网络；脑电；可视化；癫痫；大脑网络 Abstract: Epilepsy is a kind of brain disease accompanied by transient cognitive impairment. The objective metrics for clinical diagnosis and treatment evaluation of the disease is deficient because of the heterogeneity of the pathological mechanism. Multi-channel EEG (Electroencephalogram) recording is an important technique for monitoring of brain functions. In this paper, complex network visualization is adopted to investigate the overall state of brain functions in patients with epilepsy. Transient phase locking values are 1,2 3 brought in to extract weighted frequency-dependent complex networks from resting state cortical EEG HE Yan , YU Yun-li , YANG Fan1 signals of epilepsy patients, then Pajek software and minimum spanning tree algorithm are introduced 1. School of Biology Engineering, for depiction of these complex brain networks, which provides a systematic and global visualization Guizhou Medical University, Guiyang framework for quantitation of brain characteristics of epilepsy patients, and lays a solid technical Guizhou 550004, China; 2. School of Life foundation for development of intuitive