第六章 精神分裂症相关基因.pdfVIP

Original article 1 Evidence for association of the non-duplicated region of CHRNA7 gene with bipolar disorder but not with Schizophrenia a a a c ´ ´ ´ ´ ´ Ines Ancın , Ana Barabash , Blanca Vazquez-Alvarez , Jose Luis Santos , ´ c ´ ´ b c Eva Sanchez-Morla , Jose Luis Martınez , Ana Aparicio , ´ ´ b ´ ´ b Jose Carlos Pelaez and Jose Antonio Cabranes Dıaz Objective Biological evidence in both human and animal analysis revealed a positive association of the gene with studies suggests a7 neuronal nicotinic acetylcholine BD (global-stat = 24.18, P value = 0.007) with a maximum receptor subunit gene (CHRNA7) as a suitable functional effect in the region that covered introns 3 and 4. In contrast, candidate for genetic studies in psychiatric populations. no evidence of risk variants was found in the analysis of the This gene maps to chromosome 15q13-14, a major linkage SCH sample. hotspot for schizophrenia (SCH) and bipolar disorder (BD). Conclusion Our data support the non-duplicated region In this study we examine the role of CHRNA7 in influencing of CHRNA7