刘一军教授介绍fMRI概要1.pptVIP

-- From Lang, 1999 IAPS Rating/AdSAM (PAD) 3530 Not at all Extremely 1 2 3 4 5 Surprised Fearful Angry Sad Disgusted Happy ___ ___ ___ ___ ___ ___ Cross validation ICCS2010 3789 Morris/Liu, 2009 Using AdSAM as Constraints ICCS2010 Morris/Liu, HBM 2009 ICCS2010 Reference:Mapping a Multidimensional Emotion in Response to Television Commercials Jon D. Morris,1,2* Nelson J. Klahr,2,3 Feng Shen,1 Jorge Villegas,1 Paul Wright,2,3 Guojun He,2,3 and Yijun Liu2,3* Morris/Liu, HBM 2009 Emotion dissociation at different dimensions Smoke-Craving Stimuli High Medium Low L R A novel paradigm Temporal Symmetry of brain response to the changing face vs. Spatial symmetry Faces in the Picture The Self-Portrait of A. Dürer The difference between the two hemispheres is reflected in the face. (symmetry or asymmetry) Two continuous events both physically (e.g., temporally) and psychologically (emotionally) related. Noticing the changes of facial expression of others well represents such a sequential process but having social context. In particular, changing face is a reversible process. The change of facial expression Procedure Visual Stimulation Recognition of emotional facial expressions (Ekman) with a paired-block design. Subjects Healthy volunteers (n=10, 6 f/4m, 23 – 38 yrs, right-handed): Psychological and Psychophysiological Measurements: 1. Disgust scaling questionnaire (Rozin); 2. Skin conductance (SC5-SA/Contact Precision, Psylab). MRI Scanner: 3.0 T Signa (GE). EPI BOLD Sequence: TE/TR/FA=25 ms/1500 ms/700; 17 axial slices, 8 mm thick; FOV=24 x 24 cm2; Encodings = 64x64. Image Processing: MEDX, SN, TCA and in-home programs in MATLAB. Paired-Block Design Each Run six episodes (e.g. ND, NN, DN, NF, NN, FN). Three runs for each subject. (From Neutral to Disgust) The Face Changing Z = 63 mm 61 59 57 55 35 53 33 51 31 49 29 47 27 45 25 43 23 41 21 39 19 37 17 -29 -25 -27 -31 -33 P0