乳腺癌患者月经状态改变与化疗方案及年龄的关系.pdfVIP

肿瘤2007年l2月第27卷第l2期 Tumor Vo1．27，No．12，December，2007 ·999· 。 。 ： ’ 。 ： ： 岫咖 Ex ri 0嗲．枣謦玲 乳腺癌患者月经状态改变与化疗方案及年龄的关系 周力恒，殷文瑾，陆劲松，狄根红，吴 炅，沈坤炜，韩企夏，沈镇宙，邵志敏 (复旦大学附属肿瘤医院乳腺外科，复旦大学上海医学院肿瘤学系，上海 200032) [摘要] 目的：本研究旨在探讨不同化疗方案以及患者年龄对化疗诱导停经的影响，为进一步内分泌治疗药物的选择提供 依据。方法：回顾性研究绝经前乳腺癌患者接受化疗后月经变化情况，比较不同化疗方案及患者不同年龄段月经状态变化 的差异。结果：在103例患者中，蒽环类与紫杉类化疗组的月经变化差异无统计学意义(P=0．719)。在不同年龄组中，大于 45岁患者永久性停经者的比例明显高于45岁以下患者(P0．001)。低龄患者发生停经要晚于高龄患者(P=0．001)。结 论：年龄是化疗诱导停经的重要影响因素，小于45岁的患者月经受化疗影响较小，停经多为可逆性，则内分泌治疗不适宜直 接选择芳香化酶抑制剂。紫杉类化疗药物并没有比蒽环类药物对月经影响更大。 [关键词] 乳腺肿瘤；抗肿瘤联合化疗方案；年龄因素；月经 [中图分类号] R737．9；R730．53 [文献标识码] A [文章编号] 1000-7431(2007)12-0999-04 The association of menstruation of breast cancer patients th chemotherapy regimen and aging period ZHOU Li-heng，YIN Wen-jin，LU Jin-song，DI Gen-hong，wU Jiong，SHEN Kun—wei，HAN Qi-xia，SHEN Zhen—zhou，SHAO Zhi—min (Department of Breast Surgery，Cancer Hospital，Fudan University；Department of Oncology。Shanghai Medical Col- lege，Fudan University，Shanghai 200032，China) [ABSTRACT] Objective：We aimed to study the influence of chemotherapeutic regimens and aging of breast cancer patients on chemotherapy-induced amenorrhea(CIA)and to guide the further selection of drugs for endocrine therapy．Methods：We retrospectively studied the chemotherapy-induced amenorrhea(CIA)of the premenopausal breast cancer patients and compare the difference in CIA between the patients who received different chemotherapies or at different aging periods．Results：One hundred and three women were followed up．The difference in the rate of CIA was not statistically significant between the women who received anthracycline-based chemotherapy and docetaxel—based chemotherapy(70．6％ 61．1％，P=0．719)．The occurrence rate of CIA was significantly higher in older women(45 years)than young women(≤45 years，P0．001)．CI