常见蜱疾病.pptx

;常见蜱媒疾病简介;土拉(野兔热)TULAREMIA pathogen：Francisella tularensis G. negative ，three species: American、Euro-asia and mid-asia included Reservoir：rodentia mammals and lepus vector：Dermacentor、Haemaphysalis and Ixodes Transimission：aroserial 、contact and tick bite。;Clinical feather;;SIGNS/SYMPTOM;FINDINGS FROM ROUTINE LABORATORY TESTS;Diagnosis method ;DIAGNOSTIC LABORATORY CRITERIA;Treatment;莱姆病 Lyme borreliosis（ Erythema (chronicum) migrans ）;SIGNS/SYMPTOMS LOCALIZED (WITHIN 3-30 DAYS) Erythema migrans (EM) — red ring-like or homogenous expanding rash 2. May have flu-like symptoms; DISSEMINATED (WITHIN WEEKS TO MONTHS);LATE OR CHRONIC (WITHIN MONTHS TO YEARS);FINDINGS FROM ROUTINE LABORATORY TESTS;DIAGNOSTIC LABORATORY CRITERIA;Treatment;Epidemilogy: occur: normally seen in the summer, peak in June and July endemic foci along the Northern and western China and some candidate foci Average 30,000 cases reported in world ;Epidemiology: reservoir Rodentia (Peromyscus spp.) deer tick;Vector tick Ixodes scapularis (I. dammini) – blacklegged tick; East and Midwest US I. pacificus – Western blacklegged tick; West coast I. ricinus - Europe I. persulcatus - Asia;Comments on diagonsis currently based on clinical signs supported by serology confirmation of some cases remains problematic commonly used serologic tests lack precision and accuracy cross-reactivity with syphilis, relapsing fever, leptopsirosis, HIV, RMSF, infectious mononucleosis, ;a standardized two-test approach to serologic testing for antibodies to B. burgdorferi ELISA - outer surface protein Ag more sensitive Western blot IgM ELISA for early detection of Ab PCR, LUAT for early detection of Ag in urine growth on BSK from biopsy (50% of cases) to differentiate from other Lyme-like diseases;;Prevention avoid tick-infested habitats personal protection periodic total body search for presence of ticks early removal of tick since transmission inefficient prior to at least 24 hours attachment immunization - vacci