生物玻璃的原位复合及其生物活性.pdfVIP

第21卷 第6期 材 料 研 究 学 报 Vl01．21 NO．6 2 0 0 7年 12月 CHINESE J0URNAL 0F MATERIALS RESEARCH December 2 0 0 7 生物玻璃的原位复合及其生物活性 木 陈文娟 周丽赞 王德平 黄文品 姚爱华 (同济大学材料科学与工程学院 上海200092) 摘 要 以正硅酸乙酯(TEOS)、磷酸三乙酯(TEP)、四水硝酸钙为无机前驱体，采用溶胶凝胶法原位复合聚乙烯醇(PVA) 制备钙磷硅生物玻璃，研究了工艺流程、无机相前驱体的水解时间及模板的使用等对生物玻璃性能的影响．结果表明，在生物玻璃 的原位复合中PVA模板与钙磷硅前驱体混合的工艺顺序不同，则样品的韧性不同．600℃热处理去除有机模板得到的生物的玻 璃粉体表现出较高的比表面积和较大的中孔体积，在体外生理模拟液中浸泡7 d后矿化形成的活性碳酸钙与羟基磷灰石(HAP) 微晶具有较高的生物活性． 关键词 材料合成与加工工艺，生物玻璃，聚乙烯醇模板，原位复合，生物矿化 分类号 R318，TQ174 文章编号 1005—3093(2007)06—0649—05 In-situ synthesis and bioactivity of bioactive glasses CHEN Wenjuan ZHOU Liyun WANG Deping HUANG Wenhai YAO Aihua (School ol Material Science and Engineering，Tongji University，Shanghai 200092) Supported by Basic Research Section，Shanghai Municipal Science and Technology Commission No．05DJ14006．Manuscript received November 7，2006；in revised form March 30，2007． 、 To whom c0rresp0ndence should be addressed，Tel：(021E-mail：wdpshk~mail．tongji．edu．cn ABSTRACT Calcium phosphate silicate bioactive glasses were synthesized with PVA template by sol— gel in—situ method，using the tetraethyIorthos…cate．triethyl phosphate and calcium nitrate tetrahydrate as the inorganic precursors．Different methods such as FTIR．burning test and SBF in vitro were used to investigate the effect on glass property．The resuIts show that changing the mixing sequence of PVA and the precursors．products with difierent toughness can be obtained．After heat treatment at 600℃．the organic template was eliminated and the glass powders had highly SUrface area and more mesopore volume．With highly bioactivity,calcium carbonate and hydroxyapatite(HAP)were formed through biomineralization when the powde