红外线及磁场对兔膝骨关节炎软骨损伤的影响.pdfVIP

南方医科大学学报(J South Med Univ) ·l851． 红外线及磁场对兔膝骨关节炎软骨损伤的影响 孙嘉利 ，范建中 ，宋桂植2谭晓明 ，彭 楠 ( 南方医科大学南方医院康复医学科，广东 广州 510515； 山 东省新闻出版局，山东 济南 250002) 摘要：目的探讨红外线及磁场联合作用对兔膝关节骨性关节炎软骨损伤的治疗效果。方法采用管型石膏伸直位固定 右后肢的方法将24只健康雄性新西兰成年白兔复制出膝骨关节炎模型。6周后将24只兔子全部解除石膏固定．并随 机分为4组进行实验处理，即模型组、红外线治疗组(红外组)、磁疗组及红外线和磁场联合治疗组(联合组)。分别于治 疗开始后 l、2、3周处死白兔，每组每周处死2只，观察软骨的大体改变，并切取其造模肢体股骨内髁及胫骨内侧平台关 节面软骨行组织病理学(HE染色、免疫组化及原位杂交等)检测．光镜所见依据Mankin·S评分标准评分．并作统计学处 理。结果联合组的软骨病变程度(包括软骨面的损伤及软骨细胞的增生、紊乱)有显著减轻，联合治疗比单因子治疗有 显著性差异(P0．05)，两个单因子治疗组之间没有显著差异(J口0．1)。结论联合应用红外线和磁场能有效减轻骨关节炎 的软骨破坏，并可缩短病程，提高疗效，起到相互协同作用。 关键词：骨性关节炎；软骨损伤：红外线：磁场 中图分类号：R454 文献标识码：A 文章编号：1673．4254(2007)12．1851．05 Infrared radiation and magnetic field therapy ameliorates cartilage damage in rabbits with knee osteoarthritis SUN jia-li ，FAN Jian-zhong ，SONG Gui-zhi ，TAN Xiao—ming’，PENG Nan’ ’Department of Rehabilitation Medicine，Nanfang Hospital，Southem Medical University，Guangzhou 510515，China；2Administration Bureau of Press and Publication of Shandong Province，Jinan 250002，China Abstract：Objective To evaluate the effect of infrared radiation and magnetic field therapy on cartilage damage in rabbits with knee osteoarthritis．Methods Knee osteoarthritis was induced in 24 adult New Zealand rabbits by prolonged fixation of the knee joint in extension for 6 weeks．The rabbits were subsequently randomized into control group(without treatment)， infraredtherapygroup，magneticfieldtherapygroupandthe combinedinfraredandmagneticfieldtherapygroup、Atthe end of the first， second and third weeks of the therapy， respectively，2 rabbits from each group were sacrificed to observe the general changes and histopathology of the condylar cartilage of the femur, and the findings were assessed using Mankin scores．Results Compared with other groups，the rabbits in the combined therapy group showed significantly milder cartilage