miRNA-222对口腔鳞癌细胞株OSCC-15生物学功能影响的研究.pdfVIP

目 录 中文摘要··············································································1 英文摘要··············································································4 英文缩写··············································································8 研究论文 miRNA-222 对口腔鳞癌细胞株 OSCC-15 生物学功能影响的 研究 前言··············································································9 材料与方法·····································································10 结果··············································································14 附图··············································································16 附表··············································································19 讨论··············································································20 结论··············································································24 参考文献········································································25 综述 口腔癌中miRNA 的研究进展···········································28 致谢····················································································38 个人简历··············································································39 万方数据 中 文 摘 要 miRNA-222对口腔鳞癌细胞株OSCC-15生物学功能影响的研究 摘 要 目的：口腔鳞癌 （oral squamous cell carcinomas OSCC ）是口腔颌面 [1] 部常见的恶性肿瘤之一，发病率约占口腔颌面部恶性肿瘤的80% 以上 ， 且呈逐年不断上升的趋势。目前临床上口腔鳞癌的治疗方法主要包括手术 切除、放疗、化疗、生物治疗等，但疗效不佳，预后较差。因此，探索口 腔鳞癌新的治疗方法对口腔鳞癌患者的预后有十分重要的意义。Ambros [2] 等 于 1993 年在线虫体内发现第一个microRNA(miRNA) ，即line-4 ，其 [3] 参与调节了线虫的发育进程。Calin 等 于2002 年最先报道了 mi