蔓越莓对免疫系统的影响及胃黏膜保护作用的研究.pdfVIP

中国卫生检验杂志2007年12月第17卷第 12期 Chinese Journal of Health Laboratory Technology，Dec 2007；Vol 17 No 12 2179 【论著】 蔓越莓对免疫系统的影响及胃黏膜保护作用的研究 毛光明，陈玉满，鹿伟，陈江，蔡德雷，夏勇 (浙江省疾病预防控制中心，杭州 310009) [摘要】 目的：研究蔓越莓对小鼠免疫功能的影响以及对大鼠胃黏膜急性损伤的保护作用。方法：免疫调节实验：雌 性ICR小鼠200只，体重18—22 g，按体重随机分成对照组和0．5、1．0、3．0 s／kg体重3个剂量组，小鼠经口灌胃给予 蔓越莓30 d后，分别测定免疫功能的各项指标；胃黏膜保护实验：雄性sD大鼠40只，体重180—220 g，按体重随机分 成对照组和0．5、1．0、3．0 s／kg体重3个剂量组，大鼠经口灌胃给予蔓越莓30 d后，测定损伤指标。结果：免疫调节实 验：蔓越莓高剂量组小鼠的足跖肿胀度与对照组相比明显增高，中、高2个剂量组的抗体生成细胞数明显高于对照组， 各剂量组腹腔巨噬细胞吞噬百分率和吞噬指数明显高于对照组；胃黏膜保护实验：中、高2个剂量组损伤程度明显低 于对照组。结论：蔓越莓能增强小鼠的细胞免疫功能、体液免疫功能、单核一巨噬细胞功能，并对大鼠胃黏膜急性损伤 有保护作用。 [关键词] 蔓越莓；小鼠；免疫；胃黏膜 [中图分类号】 R114 [文献标识码】 A [文章编号】 1004—8685(2007)12—2179—03 Experimental study on effects of cranberry on immune system and protection on gastric m ncosa Mao Guang-ruing，Chen Yu-mart，Lu Wei，Chen Jiang，Cai De-／el，Xht y0 (Zhejiang Center for Disease Control and Prevention，Hangzhou，310009，China) [Abstract] Objective：To study the effects ofcranberry on immune functions and protection on gastric mUCOSMethods：In the immunoloregulation test，200 female ICR mice of 18—22 g were randomly divided into control group and three dose groups of0．5。 1．0。3．0 g／kg·BW according to mice body weighL After cranberry had been administered to three dose groups of ICR mice by gavage for 30 days，indexes of immune functions were examined．In protection test on gastric mucosa，40 male SD rats of 1 80—220 g were randomly divided into control group and three dose groups of0．5，1．0，3．0 g／kg·BW according to rat body weight．After cranberry had been administered to three dose groups of SD rats by gavage for 30 days，damage indexes were examined．Results： In the immunoloregulation test，tumefaction degree of mou