生长因子复合支架材料在即刻种植周围骨缺损中的作用汇编.doc

生长因子复合支架材料在即刻种植周围骨缺损中的作用 杨玉鹏1，杨圣俊2，程凤峡1，谷建琦1，郑 瑶1，李 娟1，郝 玮1，吴永生1 (河北省人民医院，1口腔科，2公费医保办，河北省石家庄市 050051) 引用本文：杨玉鹏，杨圣俊，程凤峡，谷建琦，郑瑶，李娟，郝玮，吴永生. 生长因子复合支架材料在即刻种植周围骨缺损中的作用[J].中国组织工程研究，2017，21():165-170. DOI:10.3969/j.issn.2095-4344.2017.02.001 ORCID: 0000-0002-8010-0583(杨玉鹏) 文章快速阅读： 文题释义： 即刻种植：指的是在拔牙后，即刻植入人工种植体。关于拔牙后种植体植入的时机，目前共识性的分类分为4类，即刻种植为第一类，其定义为拔牙后即刻植入种植体；其中第二类和第三类可归于拔牙后早期种植(early implant placement)；第四类种植时机亦称为后期种植(late implant placement)。 锶磷灰石：是一种新型的磷灰石类陶瓷，由锶()置换羟磷灰石[(PO4 )6(OH)2 ]中的部分钙()而制成。作为替代人体硬组织的生物材料许多学者对其进行了各种体外测试证实比传统的羟磷灰石有较大的优越性。 Growth factor composite scaffolds for bone defect repair via immediate implantation of bone defects Yang Yu-peng1, Yang Sheng-jun2, Cheng Feng-xia1, Gu Jian-qi1, Zheng Yao1, Li Juan1, Hao Wei1, Wu Yong-sheng1 (1Department of Stomatology, 2Medical Insurance Office, Hebei General Hospital, Shijiazhuang 050051, Heibei Province, China) Abstract BACKGROUND: Nerve growth factor has been shown to play an important role in bone healing, but little is reported on the effect of growth factor composite scaffolds via the immediate implantation in the repair of canine bone defects. OBJECTIVE: To analyze the effect of nerve growth factor composite scaffolds via the immediate implantation for the repair of canine bone defects. METHODS: Nerve growth factor composited strontium apatite scaffolds were prepared. Canine mandibular defect models were established and divided into three groups, followed by implanted with composite scaffold (experimental group), strontium apatite (positive control group), or nothing (blank control group). The three-dimensional CT reconstruction and hematoxylin-eosin staining of canine mandibular bone defects were observed. RESULTS AND CONCLUSION: In the blank control group, there were few new bones surrounding bone defect. Trabecular bones spread from the defect center to the surrounding tissues in the experimental and positive control groups. The bone density, volume, thickness, and implant-bone contact were s