药物化学英文版_抗肿瘤药.ppt

Thank you 班级：制药一班 学生：张航 Company Logo LOGO Company Logo Company Logo Company Logo Company Logo Company Logo Company Logo Company Logo Company Logo Company Logo Company Logo Company Logo Medicinal Chemistry  Antineoplastic Agents 班级：制药一班 学生：张航 Antineoplastic Agents Tumor formation 1 introduction 2 Basic theory Antineoplastic Agents 1 Agents Directly Acting on DNA 2 Agents Interfering with DNA Synthesis 3 Antimitotic Agents 4 Agents on Signal Transduction Pathway Mechanism of Tunor(Erlotinib) Tumor prevention 1 Primary prevention of tumor? 2 Secondary prevention of tumor? 3 Tertiary prevention of tumor? Antineoplastic Agents Tumor formation 1、Introduction Antineoplastic Agents 1)Basic characteristics of Tumor cells ——cellular atypia 2)Biological behavior of tumors ——heterogeneity Antineoplastic Agents Normal cell Carcinogen-induced change Tumor cell variant Antineoplastic Agents Tumor formation 2 Basic theory 1)Cancer is a genetic disease 2)Monoclonal expansion of Tumor cells 3)Oncogene activation or tumor suppressor gene inactivation 4)Long-term, phased, multiple mutations accumulated in the process 5)The result of loss of function of immune surveillance Antineoplastic Agents Antineoplastic Agents 1)Agents Directly Acting on DNA Alkylating Agents Platinum Complexes Topoisomerase Inhibitors 2)Agents Interfering with DNA Synthesis Antifolates Pyrimidine Antimetabolites Purine Antimetabolites Antineoplastic Agents 3)Antimitotic Agents Antitumor Agents Having One Binding-Point on Tubulin Antitumor Agents Having Two Binding-Point on Tubulin Antitumor Agents Acting on the Polymerization State of Microtube 4)Agents on Signal Transduction Pathway Mechanism of Tunor Protein Kinase Inhibitors Proteasome Inhibitors Antineoplastic Agents Erlotinib and Gefitinib Antineoplastic Agents Antineoplastic A