靶向分子适配文献总结报告.ppt

Aptamer 应用文献总结 靶向药物传递 Aptamer-functionalized PEG－PLGA nanoparticles for enhanced antiglioma drug delivery (2011,Biomaterials) AS1411 DNA aptamer 5‘-TTGGTGGTGGTGGTTGTGGTGGTGGTGG-3’ 胶质瘤细胞（C6 glioma cell ） PEGylated Anti-MUC1 Aptamer-Doxorubicin Complex or Targeted Drug Delivery to MCF7 Breast Cancer Cells（2011，Macrolecular Bioscience） MUC1 DNA aptamer 乳腺癌细胞（MCF7） Novel Aptamer-Nanoparticle Bioconjugates Enhances Delivery of Anticancer Drug to MUC1-Positive Cancer Cells In Vitro（2011，PolS ONE） A modified aptamer S2.2-spacer : 5‘-GCA GTT GAT CCT TTG GAT ACC CTG GTT CCC TTC CTT CTC TCT TCC TCT CTC CTT CTC TCT TCC TCT CTC CTT C-3’ 乳腺癌细胞（MCF-7） Aptamer-Conjugated DNAIcosahedral Nanoparticles As a Carrier of Doxorubicin for Cancer Therapy（2011，ACS NANO） MUC1 aptamer MCF-7 Engineering of Targeted Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake Selection（2012，ACSNANO） XE02/XE06/XE09 A10 前列腺癌细胞（PC3 cell） A liposome-based nanostructure for aptamer directed delivery（2010, Chem. Commun） Sgc8 T淋巴细胞急性白血病细胞（CEM) Quantum Dot-Aptamer Conjugates forSynchronous Cancer Imaging, Therapy, and Sensing of Drug Delivery Based on Bi-Fluorescence Resonance Energy Transfer（2007，NANO LETTERS） A10 PMSM 前列腺癌细胞（LNCaP cell） Aptamer-functionalized magnetic nanoparticle-based bioassay for the detection of ochratoxin a using upconversion nanoparticles as labels（2011，Analyst） OTA aptamer 5‘-GAT CGG GTG TGG GTG GCG TAA AGG GAG CAT CGG-C6-biotin-3’ 赫曲霉素（OTA） 靶向光热治疗、光动力治疗 Gold Nano-Popcorn Attached SWCNT Hybrid Nanomaterial for Targeted Diagnosis and Photothermal Therapy of Human Breast Cancer Cells（2011，ACS APPLIED MATERIALS INTERFACES） S6 aptamer 乳腺癌细胞（SK-BR-3） Regulation of Singlet Oxygen Generation Using Single-Walled Carbon Nanotubes（2008，JACS） B细胞淋巴瘤细胞Romas cell 靶向基因治疗 Molecular imaging of a cancer-targeting theragnostics probe using a nucleolin aptamer- and microRNA-221