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Journal of Organic Chemistry Research 有机化学研究, 2017, 5(1), 45-50
Published Online March 2017 in Hans. /journal/jocr
/10.12677/jocr.2017.51007
Anti-Aging Substances from Maca
Supercritical Extract
1 1 1 2 2 1
Lihong Cheng , Yanfei Lin , Yanhui Wang , Pak Kum Ju , Kim Tae Seok , Lan Xiang ,
Yeo IK-Hyun2, Jianhua Qi1*
1
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou Zhejiang
2
Institute of Food Culture, Pulmuone Co., Ltd., Seoul Korea
th th st
Received: Mar. 15 , 2017; accepted: Mar. 28 , 2017; published: Mar. 31 , 2017
Abstract
Extracts of several products of Pulmuone were screened for their anti-aging activity using the
K6001 yeast strain bioassay system. Maca supercritical extract significantly exhibited anti-aging
activity and two active compounds were isolated from the extract. The structures were elucidated
by the spectroscopic data and comparison with those reported. One structure was proposed to be
n-benzyl-(9Z)-octadecenamide (1), and another was identified as n-benzylmyristamide (2). Both
compounds significantly extended the replicative lifespan of K6001 yeast strain. To confirm the
structure of compound 1, n-benzyl-(9Z)-octadecenamide (1) was synthesized and biological activ-
ity was evaluated. The synthesized n-benzyl-(9Z)-octadecenamide (1) is identical to natural com-
pound 1 from spectroscopic data and biological activity.
Keywords
Maca, Anti-Aging, Macamides, Yeast K6001 Strain
玛咖超临界提取物中的抗衰老
活性物质
1 1 1 2 2 1 2 1*
程丽红 ,林燕飞,王艳惠,朴金株,
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