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pla微球持续释放rrigf-1对2型糖尿病大鼠种植体骨结合的影响
虫 国旦膣登擅堂盘盍至Q塑生筮! 垒鲞筮呈翅 ·8l ·
t ake n t o det ect bl oo d shco舱and se r u m i nsul i n l ev e l s i n t he di abet i c r at s .And t i l t i ng t he r at s who we r e not t O f i t t he r equi r ed i nde-
xes .Then i us et i ng t he t i t ani um i mpl ant s( . ×6r am) i nt o t he t ib i ae o f t he ot he r GKr at s .Rat model of t ype 2 di abet es i n du ced by hi gh
—f a t —car b onhydr at e di e t f or i mp l ant r es ear ch i n GKr a t wer e comp l et ed .Res ul t :Th e bl ood gl ucos e a nd s euil n i ns ul i n l evel i n t he
hi gh—f at —car b onh ydr at e f ;eds GKr at s wa a s i gni fi c ant l y i ncr eas e d,and t he B c el l s we r e n ot dema ge d s i gni f i c ant ly .The i mpl ant s i n t he
t ib i ae o f t he GK r a t a we r e st ab l e .Di scus si on :Ge ner al l y di abet i c ani mal model f r om a rt i f i ci a l i nduct i o n wa s t o i nj e ct s t r ept oz ot oci n i n
l ow dos e a nd f ed wi t h hi g h—f 乱一ca r bon hydr a t e di et ,but s t r ept oz ot oci n wou l d dema ge t he B c e ll s ,and wha t f ol l ows next i s neor obi os i s ,
a l l t hese sho ul d bel ong t o t yr o l di a bet e s .He r e t he di abet es model f r om t he hi sh—f at —car b onh ydr at e di et i n du ced h ad bl ood s l uco鸵
l evel s i gni f i cant l y i nc r eased a nd no? ce l l s dema ge s i gni f i c ant l y .t he t i t ani um i mpl ant s( 。 ×6mm) a l s o f i t t he anat o mi c f o r m o f t he
t ib i ae o f GK r a t s .Conc l us i on :The model i s an i de a l one f or t he st udy on t ype 2 di abet es mel l it us f or i mp l ant r ese a r ch .
PLA微球持续释放r r l GF—l 对2型糖尿病
大鼠种植体骨结合的影响
王峰宋应亮
( 第四军医大学口腔医院种植科,陕西西安7 100
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