慢性肾功能衰竭患者血清瘦素水平变化及治疗的影响.pdfVIP

巾国医药导刊 ·477· 2007年 第9卷 第6期 (总第53期) 慢性肾功能衰竭患者血清瘦素水平变化及治疗的影响 孙芳 彭立人 徐晨 (北京朝阳医院。肾内科，北京 100020) 【摘要】目的：观察慢性。肾功能衰竭(CRF)患者血清瘦素(Lp)水平变化，以及CRF的治疗如促红素(EPO)、血液透析、。肾移 植，对CRF患者Lp水平的影响。方法：选择CRF患者(肌酐5mg／dL)150例(实验组)，健康志愿者6o例(正常对照组)； 将实验组分为以下几个亚组：①未透析组；②血液透析组；③肾移植组；再根据EPO治疗情况分EPO治疗组和非EPO治 疗组，分别于空腹取静脉血，测定Lp水平。再从血液透析组中选取患者30例(规律透析2—156个月)分为：常规血液透 析组、血液透析滤过组和高通量透析组，测量单次透析前后 水平。上述分组均按性别、年龄、体重指数匹配原则进行。 结果：①CRF患者 水平较正常对照组明显增高，有显著性差异；②应用EPO治疗后，,CRF患者Lp水平下降；③常规血 液透析对CRF患者Lp清除差，而高通量透析、血液透析滤过对CRF患者Lp水平的影响可降低30％，肾移植对CRF患 者Lp水平下降有显著差异。结论：CRF患者 水平较正常对照组明显增高，高通量透析、血液透析滤过及肾移植可以部 分降低CRF患者Lp水平。 【关键词】瘦素；慢性肾功能衰竭；血液透析 【中图分类号】R541．4 【文献标识码】A 【文章编号】1009—0959(2007)06—0477—03 Serum Lepfin Level in Patients with Chronic Renal Failure and the Influention by the Treatment Sun Fang，PengLi—ren,Xu Chen ((Department of Re衄1 Internal Medicine，Beijing Chaoyang Hospital，Beijng 100020，China) 【ABS3RACr】Objective：The article was to survey the seruln leptin leval in chronic renal failure patients and the influention by the treatment，such as EPO，hemedialysis and renal transplant．Methods：The seruln leptin was measured in 150 patients with CRF and in 60 healthy controls．The trial group was divided into several subgroups：non hemodialysis group，bkN~d p group and renal trans- plant group．And according to EPO，they ale divided into two groups again：rHuEPO treatment group，no rHuEPO treatment group．The blood p~ify group Was divided into nomml hemodialysis group，hemodiafihration group and hi flux hemodialysis group．The seruin lep- tin level was determined by radioimmunoassy，Reslll姆：OThe seruln leptin level in patien