眼刺激试验替代方法研究进展_廖艳2004剖析.pdfVIP

2004 8 August, 2004 14 　4 CHINESE JOURNAL OF COMPARAT IVE MEDICINE Vol.14 　No.4 3R 1 2 1 2 3 廖　艳, 王　雪, 张立实, 李冠民, 张宝旭 (1., 　610041;2.;3.) 　　【】　(D aize test)“3R”, 。 , , 。 【】　;; 【】R779.13　　【】A 　　【】1671-7856(2004)04-0229-05 Study Advance in the Alternative Methods of Draize Eye Irritation Test 1 2 1 2 3 LIAO Yan , WANG Xue , ZHANG Li-shi , LI Guan-min , ZHANG Bao-xu (1.West China School of Public Health, Sichuan Unive sity, Chengdu 610041, China;2.National Institute fo the Cont ol of Pha maceutical and Biological P oducts;3.School of Public Health, Beijing Unive sity) 【Abstract】　On account of the limitation of D aize eye i itation test, alte native methods in vitro fo D aize test have been developed and validated ecently, with the p ospe ity of the “th ee Rs” movement.Because they have diffe ent mechanisms and peculia ities, a batte y of such methods should be fixed to evaluate the eye i itation of chemicals. 【Key words】　Eye i itation test;In vitro;Animal testing alte native 　　(D aize eye i itation test, D aize D aize test : test )20 40 , , 、 [2] 。D aize test , 。 , D aize test ( [ 1] ), “3R” , [3, 4] 。 。D aize 。 test D aize test , 、 1　D aize test 、 D aize test 1944 D