基于听觉响应时间的麻醉效果监测-南方医科大学学报.PDF

·1824 · 南方医科大学学报（J South Med Univ ） 2011;31(11) ·基础研究· 基于听觉响应时间的麻醉效果监测 1 1 2 1 解小丽 ，徐月晋 ，肖中举 ，周凌宏 1 2 南方医科大学 生物医学工程学院，基础医学院，广东 广州 510515 摘要：目的探索麻醉代谢过程中听觉系统相关参数的变化，为动物实验中麻醉效果的正确评估建立监测指标。方法 选 取4~6 周的BALB/C 小鼠，手术方法暴露下丘组织，用乌拉坦进行麻醉，选取纯音作为刺激条件，记录麻醉代谢过程中小 鼠下丘的听觉局部电位波形，并用matlab 软件提取波形的潜伏期和幅度数值，分析二者随麻醉剂的代谢而呈现的变化。 结果 与幅度相比，小鼠听觉局部电位的潜伏期数值变异性小，且与时间有较好的相关性。在乌拉坦代谢过程中，潜伏期 随麻醉代谢过程逐渐下降，其中前2 h 下降较快，后期逐渐趋于稳定。结论 听觉局部电位的潜伏期比幅度更适合作为麻 醉效果的监测指标。 关键词：麻醉效果监测；听觉局部电位；乌拉坦 中图分类号：R764; 624 文献标志码：A 文章编号：1673-4254（2011）11-1824-06 Monitoring of anesthetic effect based on auditory response time 1 1 2 1 XIE Xiao-li , XU Yue-jin , XIAO Zhong-ju , ZHOU Ling-hong 1School of Biomedical Engineering, 2 Shool of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China Abstract: Objective To investigate the changes of auditory parameters during anesthesia and establish the assessment indicators for anesthesia monitoring in animal experiments. Methods BALB/c mice of 4 to 6 weeks were given a single intraperitoneal dose of urethane, and the auditory evoked potential in the surgically exposed inferior colliculus in response to pure tone stimulation was recorded during urethane metabolism. The latency and amplitude data of the waves were extracted using Matlab software to analyze their variations during urethane metabolism. Results The latency of the auditory evoked potential showed slight variation and was well correlated to time. The late