载脂蛋白e 基因多态性与汉族人群心肌梗死的相关性 - 中华临床医师杂志.pdfVIP

²284 ² 中华临床医师杂志( 电子版)2017 年1 月第11 卷第2 期 Chin J Clinicians(Electronic Edition),January 15,2017,Vol.11,No.2 ²综述² 载脂蛋白E 基因多态性与汉族人群心肌梗死的相关性 焦敏 邱龄 曹芸汐 【摘要】 心肌梗死（MI ）是一种复杂的综合征，同时受到多种遗传基因和环境因素的影响， 基本病因是冠状动脉粥样硬化。对于载脂蛋白E （ ApoE ）基因多态性和MI 危险因素之间的关系已 经研究了近40 年，仍然未能达成一致的观点。近几年，MI 与基因-基因、基因-环境的相互作用越来 越被学者所认可，因此，ApoE 基因多态性也成为全球学者研究的热点。 【关键词】 心肌梗死； 载脂蛋白E 类； 基因多态性 Association between apolipoprotein E polymorphism and myocardial infarction in the Han population Jiao Min, Qiu Ling, Cao Yunxi. Department of Cardiology, the Second Hospital of Shanxi Medical University, Taiyuan 030000, China Corresponding author: Qiu Ling, Email: Oldnestle@ 【Abstract 】 Myocardial infarction is a kind of clinical common complex syndrome. The disease occurs on the basis of coronary artery lesions. The basic pathological change of myocardial infarction is coronary atherosclerosis, and its pathogenesis is influenced by a variety of genetic and environmental factors. The relationship between apolipoprotein E gene polymorphism and the risk factor for myocardial infarction has been studied about 40 years, however, the results are still inconsistent. In recent years, the interaction between myocardial infarction and gene-gene, gene-environment is more and more accepted by the scholars. As a result, the apolipoprotein E gene polymorphism becomes a hot spot of academic research in the world. 【Key words 】 Myocardial infarction; Apolipoprotein E; Gene polymorphism 心肌梗死（myocardial infarction ，MI ）是指心 ApoE 作为血清中多种脂蛋白的重要构成成 肌的缺血性坏死，多是在冠状动脉病变的基础上， 分，是一种多功能蛋白质，在体内甘油三酯和胆固 [3] 发生冠状动脉血供急剧减少或中断，导致下游心肌 醇的新陈代谢中起重要作用 ，所以该基因对 MI 严重而持久的缺血所致。通常原因为在冠状动脉不 的作