紫茎泽兰基芳香防蛀缓释剂的制备与性能研究 - 中国农学通报.pdfVIP

中国农学通报 2013,29(18): 175-179 Chinese Agricultural Science Bulletin 紫茎泽兰基芳香防蛀缓释剂的制备与性能研究 王 凤，赵 静，刘 强，刘文浩 （北京化工大学，北京100029） 摘 要：为了制备紫茎泽兰基芳香型防蛀缓释剂，通过可压性和开放式体外释放实验，确立了适宜在片剂 中添加的吸附剂和赋形剂，并探讨了制剂组成和制备工艺条件对片剂释放性能的影响，通过药效试验测 定片剂的药效。结果表明，微粉硅胶具有较好的可压性及控释作用，适宜添加在片剂中；以紫茎泽兰草 粉为载体，在10 MPa 压力下可成功制备外形完好的紫茎泽兰基芳香防蛀缓释片剂，片剂中紫茎泽兰草 粉用量可高达片剂质量的76% (m/m) ，且香味持留时间可达3 个月以上；薰衣草香精的加入不仅能掩盖 草粉的不愉悦气味，还能提高片剂的药效。本研究中芳香防蛀缓释剂的成功制备，不仅拓宽了紫茎泽兰 的综合利用范围，也为国内防蛀剂市场提供了一个具有增香的多功能防蛀缓释剂。 关键词：紫茎泽兰；薰衣草香精；微粉硅胶；缓释 中图分类号：S482.3 文献标志码：A 论文编号：2012-1888 Preparation and Release Kinetics of Multi-functional Mothproofing Sustained-release Tablets Based on Eupatorium Powders as a Carrier Wang Feng, Zhao Jing, Liu Qiang, Liu Wenhao (BeijingUniversityofChemicalTechnology, Beijing 100029) Abstract: In order to prepare the aromatic and mothproofing sustained-release tablets based on eupatorium powders, the absorbents and excipients appropriately incorporated into the tablets were selected by using compression formulation experiment and in vitro release experiment. The influence of the compositions of the tablets and formulation conditions on the release kinetics was investigated using in vitro dynamic release experiments. The efficacies of tablets were evaluated by test insects. The results showed that: Micro-silica powders appropriately incorporated into the tablets had good compressibility and controlled-release effect. The sustained-release tablets could be successfully prepared by using eupatorium powders as a carrier and the formulation pressure of 10 MPa. The obtained lavender flavor-containing eupatorium-based tablet