1型糖尿病患者血清25（oh）d3水平与锌转运8自身抗体的相关研究.docVIP

新诊断的1型糖尿病患者血清 25羟维生素D3水平与锌转运8自身抗体的相关研究 罗娜 杨涛* 王知笑* 张真稳 王艳 朱妍 【摘要】目的：探讨血清25羟维生素D3[25（OH)D3）]水平与新诊断的1型糖尿病（T1DM）25(0H)D3水平与ZnT8A抗体滴度的关系。结果：1.与正常对照组的血清25羟维生素D3水平(69．4±9．2 nmol／L)比较，T1DM组(36.8±6.1 nmol／L )的血清25(0H)D3水平显著降低(P0.01)；在维生素D缺乏人群中，T1DM的患病风险增加(OR值=3．16；95％的可信区间：（3．02～3．31)；2.根据25（OH）D3水平由高到低分为三组，结果发现空腹及餐后C肽水平逐渐降低（P0.05）;维生素D缺乏组与维生素D充足组比较,Zn8TA阳性率升高（P0.05）;3.ZnT8A阳性率与25(0H)D3水平负相关（r=-1.036,P0.05）T1DM患者血清25(0H)D3水平较低，在维生素D缺乏的人群中T1DM的患病风险增高；2. 血清25(OH)D3水平可能影响ZnT8A阳性率。 关键词：血清25(OH)D3 1型糖尿病 锌转运8自身抗体 The Correlation Study of Serum 25-Hydroxyvitamin D3 and zinc transporter 8 antibodies in newly diagnosed type 1 diabetes mellitus Luo Na, Yang Tao，Wang Zhi Xiao，Zhang Zhenwen,Wang Yan，Zhu Yan. Department of Endocrinology,Subei Hosipital,Yangzhou 225000，China Coeeesponding author:Zhu Yan.Email: sbyyzy@ Abstract Objective To evaluate the association of 25-Hydroxyvitamin D3 [25(OH)D3] and zinc transporter 8 antibodies in newly diagnosed type 1 diabetes mellitus.Methods There were 32 newly diagnosed type 1 diabetes mellitus and 100 controls in study . Clinical data were collected, biochemical parameters, serum 25 - hydroxyvitamin D3 levels and ZnT8A were detected;The relevance of serum 25 (0H) D3 and ZnT8A were analyzed. Results:1. Serum 25(OH)D3 level was 作者单位：江苏省苏北人民医院 作者简介：罗娜，女，主治医师。现工作单位：扬州市苏北人民医院。联系电话email：planternana@163.com *杨涛 ，王知笑，现于江苏省人民医院内分泌科工作。 通讯作者：朱妍，江苏省苏北人民医院。Email:sbyyzy@ 基金项目：国家自然科学基金资助项目３０９７１４０５） significantly lowerer in T1DM than that in the controls(P0.01). In the Vitamin D deficiency group, the prevalence of T1DM were increased,risk odds ratio (OR = 3.16; 95% confidence region:(3.02 - 3.31);2 From vitamin D sufficient group to vitamin D deficient group,fasting and postprandial C-peptide level were gradually decreased（P0.05）;the ZnT8A positive rate in vitamin D deficient group was higher than vitamin D sufficient group (P0.05).3. The ZnT8A positive rate was negative related with serum 25(OH)D3 concentra