中药复明片治疗原发性开角型青光眼视功能损害的疗效.docVIP

　　中药复明片治疗原发性开角型青光眼视功能损害的疗效 【摘要】 　　目的：探讨中药复明片对原发性开角型青光眼视功能损害的治疗作用。方法：对用药物或手术控制眼压≤2.99kPa（21mmHg）的原发性开角型青光眼36例65眼随机分为复明片治疗组和甲钴胺片对照组。治疗组给予复明片（西安碑林药业），5片3次/d，对照组给予甲钴胺片，0.5mg 3次/d，30d 1疗程，治疗3疗程后，复查mfERG及进行HRT视盘扫描分析。 结果：复明片治疗组患者mfERG N1波1环的振幅密度与对照组比较明显提高，5环的振幅密度与治疗前相比明显提高，P1波1，2，5环的振幅密度与治疗前相比均明显提高。复明片组治疗后视乳头盘沿面积（mm2）、视杯容积（mm3）、平均RNFL厚度（mm）与甲钴胺片对照组比较有改善，RNFL截面面积（mm2）与治疗前比较明显增大。结论：复明片对开角型青光眼患者具有较好的疗效，可以明显改善患者mfERG的振幅密度及改善患者视乳头部分结构参数，mfERG和HRT可以做为评估其有效性的敏感方法。 【关键词】 青光眼　复明片　多焦视网膜电图　海德堡视网膜断层扫描仪 　　Study of the Fumingpians curative effect to the visual function damage of primary open angle glaua Abstract AIM: To discuss the Fumingpians therapeutic effect to the visual function damage of primary open angle glaua. METHODS: Thirty-six case 65 eyes of IOP≤2.99kPa (21mmHg) controlled by medicine or operation ly separated into tingpian therapy group and Mecobalamin tablets parison group. The therapy group had Fumingpian (Xian Beilin Pharmaceutical Co.,LTD. ), 5 pieces tid, and the parison group had Mecobalamin tablets, 0.5mg tid. After 90 days, the mfERG and the HRT in tablets parison group, the therapy groups N1 plitude density of mfERG proved obviously. paring to the Fumingpian therapy group, the 5 rings amplitude density proved obviously, and the P1 plitude density proved obviously. Therefore, the therapy groups optic papilla disks area, optic cups cubage, average RNFLs thickness proved by paring to the parison group and the RNFLs section area augment paring to the front of the therapy. CONCLUSION: Fumigpian has good curative effect to the open angle glaua patients. It can improve the patients mfERGs amplitude densityand the patients part optic papillas construction parameter. So the mfERG and HRT can be a sensitivity method to evaluate its efficacy. · KEYecobalamin）a-（5，6-二甲基苯并咪唑基）-Co-甲基-钴胺酰胺。药理：（1）促进核酸、蛋白的合成；（2）促进轴索内轴流和轴索再生；（3）促进髓鞘形成（磷脂合成）；（4）对神经轴突传递的延迟和神经传递物质减少的恢复。适应症：周围神经病。 1.2方法 1.2.1药物治疗 治疗组给予中药复明片（西安碑林药业），1次5片，3次/d。对照组给予甲钴胺片，1次1片（0.5mg），3次/d，30d 1疗程，连续3疗程，治疗期间停用其他药物。两组病