微流控技术在纳米粒药物输送系统中的应用the - 药学学报.pdf

· · 药学学报 Acta Pharmaceutica Sinica 20 17, 52 ( 期): 起页 末页(校样) 1 流控技术在纳米粒药物输送系统中的应用 * 郭希颖，魏巍，王坚成，张强 （北京大学 学院，分子 剂学与新释药系统北京市重点实验室，北京 100191 ） 摘要: 微流控是利用微纳米级尺度的管道来处理和操控流体所涉及的一门技术。利用微流控精准 控制层流液体或液滴混合效应可实现传统常规液体混合方法难以完成的纳米粒制备。本文以纳米 物输送领域的研究进展为切入点，主要介绍微流控技术在脂质体、聚合物纳米粒和杂化纳米粒等纳 米粒药物输 系统构建中的应用，并剖析其在不同结构的纳米组装体精准控制作用机制。本综述将 为纳米药物输 系统领域的研究者如何更科学合理地利用微流控技术提供借鉴参考。 关键词: 微流控；纳米粒 物输 系统；制备；构效关系 中图分类号: R943 文献标识码: A 文章编号: 0513-4870 (20 17) The applications of microfluidic technology in nanoparticulate drug deli- very systems * GUO Xi-ying, WEI Wei, WANG Jian-cheng , ZHANG Qiang (Beijing Key Laboratory of M olecular Pharmaceutics and New Drug Delivery Systems, School of Pharmaceutical Sciences, Peking University, Beij ing 100191, China ) Abstract : Microfluidic is a technology that involves the use of micro-nanoscale pipelines to manipu- late fluid mixing. To precisely control the mixing process of laminar flows or liquid droplets by using mi- crofluidic will contribute to the preparation of nanoparticles which are difficult to be achieved by conven- tional methods. Based on the progress in nanoparticulate drug delivery systems, this review mainly focuses on introducing the applications of microfluidic in construction of nanoparticulate drug delivery system such as liposomes, polymer nanoparticles and hybrid nanoparticles, and analyzing the assembling mechanisms of different nanostructures by using microfluidic precise control. This review will provide references for researchers t