人类与医学遗传学5生物信息学.pptVIP

CAPS is more conserved in vertebrate Halabi, et al., 2009, Cell, 138: 774 Red sector Blue sector CAPS: Complexity Associated Protein Sectors 复杂相关域 (blue sector) Protein Sectors: Evolutionary Units of Three-Dimensional Structure Halabi, et al, Cell, 2009, 138: 774 0123456789 0123456789 0123xxxxxx A B’ A’ 0123xxxxxx A 012345xxxx Bx C B C 0123451321 0123451321 Genetic equidistance explained by the MGD hypothesis 最大遗传变异学说解释遗传等距离现象 X 对 X 距离为1 Complexity 最大遗传变异假说是遗传等距离现象的理论基础 实际重叠 人 果蝇 酵母 12 预测重叠 人 果蝇 酵母 12