针刺对粘连性肠梗阻大鼠肠黏膜超微结构的影响.pdfVIP

· 1094· 辽宁中医杂志 8 箜 鲞釜! 针刺对粘连性肠梗阻大鼠肠黏膜超微结构的影响 李 红 。吴健文 。陈尚杰 ，刘鉴慰 。张家维 (1．广东省中医院，广东 广州510407；2．广州中医药大学针灸推拿学院，广东 广州510405) 摘 要：目的：探讨针刺对粘连性肠梗阻大鼠预防作用的机理。方法：建立粘连性肠梗阻大鼠模型，对大鼠肠黏膜的 超微结构进行研究。结果：术后小肠黏膜上皮细胞微绒毛减少，线粒体和粗面内质网明显减少，炎性细胞浸润增多。针 刺能明显改善肠梗阻时小肠组织超微结构的损伤，促进线粒体和粗面内质网功能和形态恢复。结论：针刺能够改善术后 肠道黏膜上皮细胞异常的超微结构，增强肠黏膜的防御屏障功能。 关键词：粘连性肠梗阻；针刺；超微结构；中医药治疗 中图分类号：R246 文献标识码：B 文章编号：1000—1719【2008)07—1094—03 Effects of Acupuncture on the Altrastructure of Intestinal M ucosa in Rats with Adhesive Intestinal Obstrucfion Injury Hong ，WU Jian—wen ，CHEN Shang一 ，LIU Jian—wei ，ZHANG D—wet (1．Guangdong Provicial Hospital of TCM，Guangzhou 510407，Gnangdong，China；2．Acupuncture—Moxibustion ＆Massage College。Guangzhou University of Chinese Medicine，Guangzhou 510405，Gnangdong，China) Abstract：0 ctive：In order to investigate the mechanism for acupuncture in proproteeting the intestinal mucosa in rats af- ter adhesive intestinal obstruction injury．Methods：The effects of acupuncture on the ultrastructure of intestinal mucosa were stud— ied in adhesive intestinal obstruction injury rat models with electon—microscope．Resuhs：The amounts of mierovilli．mitochon— dria and FOUgh surface endoplasmie retieulum(RSER)were all decreased，infiltration of inflammatory cells were increased under the electromicroscope．Acupuncture Call improve the ultrastructure injury of the obstructive intestinal tissues，promote the recov— ery of both the funetion and morphology,of the mitochondria and RSER．Conclusion：Acupuncture eaIl improve the ultrastructure iniury of the obstructive intestinal tissues and enhance the defenee—barrier function of intestinal mucosa． Key words：adhesive intestinal obstruction；acupuncture；altrastrueture；TCM therapeutics 粘连性肠梗阻是肠