脂组学在医药研究中的应用+论文.pdfVIP

脂组学在医药研究中的应用 陆姝欢，杨松，元英进 （天津大学化工学院制药工程系，天津300072，中国） 摘要：生物机体生理状态的改变与脂代谢紊乱有密切联系，脂组学通过对生物机体内的脂代谢物及 与其作用的生物分子进行系统分析，揭示在不同生理状态下生物机体内脂代谢网络的变化情况及脂 生物标志物。电喷雾/质谱技术是脂组学的研究基础，它能对脂代谢物，尤其是磷脂进行灵敏有效 的高通量分析，促进了脂组学在疾病诊断、治疗、新药研发及药物作用机制研究等领域的应用。脂 组学可加深对脂代谢物作用机制的了解，为药物研制和开发提供新的契机，在医药研究领域中表现 出广阔的应用前景。 关键词：脂组学；电喷雾/质谱技术；脂生物标志物；医药研究 Application of Lipidomics in Medicine and Drug Development LU Shu-huan, YANG Song, YUAN Ying-jin (Department of Pharmaceutical Engineering， School of Chemical Engineering and Technology ，Tianjin University ，Tianjin 300072，China) Abstract: Lipids are essential cellular constituents that have multiple distinct critical roles in cellular function, such as providing the structural basis of cell membranes, serving as fuel for metabolism, and mediating cellular signal transduction. Lipid levels are tightly regulated, spatially and temporally, in the various parts of the human body. It is attractive to propose that deregulation of this network contributes to the onset of pathology. This idea is indeed supported by a wide variety of human diseases that are associated with aberrant lipid metabolism. Examples of such diseases include cancer, diabetes, as well as infectious diseases. Lipidomics, after genomics and proteomics, is a newly and rapidly expanding research field of systems-level analysis of lipids and biomolecule that interact with lipids. The lipidomics, viewed as an important sub-discipline of ‘metabonomics’, help us to efficiently identify the alterations of lipid metabolic network and potential biomarkers in normal and pathological states. Recently, the development of electrospray ionization mass spectrometry (ESI/MS) has provided the found