急性铊中毒研究进展邱玲玲.pdf

2013, 33(1) ht p:// Int J Pathol Clin Med DOI:10.3969/j.issn.1673-2588.2013.01.016 ht p:///gjblkx/i leup/PDFpdf μg/Lμg/L Advance in studies on acute intoxication of thallium QIU Lingling, SONG Zhi, CHEN Ru (Department of Neurology, Third Xiangya Hospital, Central South University, Changsha 410013, China) Abstract h allium is a toxic and rare heavy metal. h ere are several common pathways for acute intoxication of thallium to human being, such as respiratory, digestive or dermal route, especially the oral way. It is known that the inhibition + + of potassium in Na -K -ATPase, the alteration of membrane physical properties, the binding with thiol enzyme, the impaired mitochondrial function and interaction with ribolavin to disrupt electron transfer may play a role in thallium toxicity. h e exact mechanisms still remain poorly understood. Neurotoxicity is the most prominent clinical symptom for thallium toxicity. When a person showed symptoms of alopecia, peripheral neuropathy together with gastrointestinal disorders, it is reasonable to consider the possibility of thallium toxicity. When the value of thallium level in blood or urinary is more than 100 μg/L or 200 μg/L, it can be used for diagnosis o