（参考翻译）04.2英文痛风.pptVIP

尿酸主要通过肾脏排泄。 肾小球滤过的尿酸，98%被肾小管重吸收，尿酸的排泄主要靠肾小管的再分泌。 痛风可发生于任何年龄，高峰年龄为40岁左右；男性占95%，女性多为绝经后妇女;多见中、老年人 女性只占5%，且多为绝经后妇女； 尿酸盐在肾间质沉积——间质性肾炎 浮肿、高血压、蛋白尿、血尿、氮质血症及尿毒症。尿酸性肾结石 肾绞痛、血尿及尿路感染 男性和绝经后女性420μmol/L 绝经前女性血尿酸350μmol/L; Undergoing a joint fluid test to check for presence of uric acid crystals. Because gout attacks can also imitate infections, a doctor might also check for offending bacteria when performing a joint fluid test to rule out infection as a possible cause of the symptoms. 大关节，游走性对称性。青年女性、小关节、梭形肿胀。多有创伤史，血尿酸不高。原发感染或化脓病灶，关节液培养 出致病菌，血尿酸不高。 如无肾脏病变引起肾功能不全，原发性痛风预后良好。 Company Logo LOGO GOUT痛 风 Department of Endocrinology the First Affiliated Hospital, Chongqing Medical University Cheng Qingfeng 程庆丰 content What Causes Gout? 2 Signs and Symptoms 3 How Is Gout Diagnosed 4 Remedies 救济方法 5 What Is Gout? 1 Definition Gout： Hyperuricemia 高尿酸血症 Arthritis 关节炎 Uratoma 痛风石 joint deformity 畸形、dysfunction Disrupt 破坏 kidney and kidney stones hyperuricemia： asymptomatic 无症状的 purine uric acid ↑ Gout： acute arthritis 急性关节炎 Tophi 痛风石 Complication of Kidney content What Causes Gout? 2 Signs and Symptoms 3 How Is Gout Diagnosed 4 Remedies 5 What Is Gout? 1 pathogenesis Text Gout Text primary secondary Text Metabolism of UA source： exogenous： endogenous ： Excretion 排泄： kidney：mainly intestinal tract 肠道： Pathogenesis and typing Generate 生成 increased： Excretion reduction： mixed content What Causes Gout? 2 Signs and Symptoms 3 How Is Gout Diagnosed 4 Remedies 5 What Is Gout? 1 epidemiology age gender Family History metabolic syndrome stage Chronic gout Interval 间歇性 gout Acute gout Asymptomatic hyperuricemia 无症状性高尿酸血症 high levels of uric acid no other symptoms Asymptomatic hyperuricemia big toe fingers Tophi Kidney damage Gout nephropathy 痛风肾病 kidney stones content What Causes Gout? 2 Signs and Symptoms 3 How Is Gout Diagnosed 4 Remedies 5 What Is Gout? 1 Diagnosis physical exam Performing 执行 blood tests joint fluid test au