02.2Hypopituitarism大课课件.pptVIP

Hypopituitarism (腺垂体功能减退症) Endocrinology department, the 1st affiliated hospital, chongqing medical university Jian long Sella turcica（蝶鞍） Bean-shaped Weight: 5 g Thyroid gland Adrenal gland Ovary 　(甲状腺）　　 　（肾上腺）　　　（卵巢） Target gland Anterior part （前叶） (Adenohypophysis) (腺垂体) Posterior part (后叶) (Neurohypophysis) (神经垂体） Pituitary stalk (垂体柄) Hypothalamus （下丘脑） 1）Positive feedback 2）Negative feedback Hypothalamus Pituitary gland Target glands （下丘脑） （垂体） Hypothalamus Pituitary gland Target glands （下丘脑） （垂体） Feedback(反馈) Hypothalamus PIF (prolactin inhibiting factor) GHRH (GH releasing hormone) LHRH (LH releasing hormone) TRH (TSH releasing hormone) CRH (Corticotropic releasing hormone) Anterior pituitary gland PRL　(Prolactin) （催乳素） GH（growth hormone）(生长激素) LH　(luteinizing hormone)(黄体生成素)FSH　(follicle stimulating hormone)（卵泡刺激素） TSH（thyroid stimulating hormone) （促甲状腺激素） ACTH　(adrenal cortex stimulating hormone)促肾上腺皮质激素) Target gland E2、E3(estrogen) T(testosterone) T3、T4 Cortisone Hormones Hypopituitarism Definition: Hypopituitarism is a condition in which the pituitary gland does not produce one or more of its hormones or not enough of them. Etiology(病因学): Primary Secondary 1、tumor 2、ischemic necrosis（坏死） 3、surgery、trauma、radiotherapy （放疗）3、infection、infiltration（浸润） 4、hereditary disease （遗传）5、autoimmune disease（自身免疫） 1.Secondary:damage to hypothalamus or pituitary stalk 2.Primary: damage to pituitary Secondary Primary Secondary Simmond disease: is one kind of hypopituitarism, which accures only in adult. Sheehan’s syndrome: is one kind of hypopituitarism, in which the decreased productions of the anterior pituitary hormones are due to ischemic postpartum（产后） pituitary necrosis（坏死） or septicemia（败血症） after delivery. Hypopituitarism Simmond disease Sheehan’s syndrome manifestation of primary