11合成含腺嘌呤和芳基脲α- 氨基膦酸(酯)的意义 - 海南省高等教育 .doc

学校代码： 11658 　　　　　　　　学 号： 200807030309 分 类 号： O629 　　 　　密　　级： 无 硕士学位论文 含腺嘌呤和芳基脲的α -氨基膦酸酯 衍生物的合成 作者姓名 孔杜林 学科专业 有机化学 研究方向 有机合成 指导教师 吴明书 教授 申请学位类别 理学硕士 提交日期 二○一一年五月  Synthesis of α-Aminophonsphonates Derivatives Containing Adenine and Aylurea A Dissertation Submitted for the Degree of Master Candidate：Kong Du Lin Supervisor：Prof. Wu Ming Shu Hainan Normal University Haikou, China 摘 要 α-氨基膦酸酯类化合物作为膦酰化氨基酸的类似物具有抗植物病毒、抑制酶活性、抗肿瘤、除草、杀菌等多种重要的生物活性。近年来，人们尝试着合成不同N杂的α-氨基膦酸酯的衍生物。腺嘌呤，芳基脲因其具有良好的生物活性，其广泛应用在医药，农药等领域。基于此，本论文以腺嘌呤，芳基脲为原料，合成了25个含腺嘌呤和芳基脲的新化合物。 1报道了以腺嘌呤，取代的醛，亚膦酸三苯酯为起始原料，在冰醋酸和二甲苯中回流反应合成了7个含腺嘌呤的α-氨基膦酸新化合物，产物结构经IR, 1H NMR, 13C NMR, 31P NMR和元素分析等进行了表征。2-羟基-1-萘甲醛，芳基脲，苯基二氯化膦作为起始原料，在无水甲苯中反应合成α-氨基膦酸酯新化合物。结构经IR, 1H NMR, 31P NMR和元素分析等进行了表征。产物结构经IR, 1H NMR, 13C NMR和元素分析等进行了表征α-氨基膦酸酯； 芳基脲；2-萘酚；合成 Abstract As the analogues of phosphoryl amino acids, α-aminophonates and their derivatives have shown to serve as herbicides, insecticides, fungicides, peptidomimetics, enzyme inhibitors and antiviral agents. In recent years, N-heterocyclic moieties were introduced into α-aminophonates in this thesis. Adenine and arylurea derivatives widely used medicine and pesticides because of their unique structural features and diverse potential biological and industrial importance. Twenty-five new compounds were synthesized using adenine and arylurea in the paper. 1 Seven novel α-aminophosphonic acids containing adenine were synthesized by t-he three component condensation reactions of adenine with triphenyl phosphite and al-dehydes in the presence of acetic acid and xylene. The product structures were chara-cterized by IR, 1H NMR, 13C NMR, 31P NMR and elemental analyses. 2 Seven novel stereospecific α-aminophonates containing arylurea were synthesized utilizing 2-hydroxy-1-naphthaldehyde, arylurea and phenyl- dichlorophosphine as starting materials in anhydrous toluene. The product structures were characterized by IR, 1H NMR, 31P NMR