转录因子scx和mkx在肌腱发育和分化中的研究进展.pdf

中国细胞生物学学报 Chinese Journal of Cell Biology 2016, 38(12): 1549– 1554 DOI: 10.11844/cj cb.2016.12.0101 转录因子SCX和MKX在肌腱发育和 分化中的研究进展 1 2 3 2 3* 吴 震 张子旺 王晓艾 郑莉灵 吴 芳 1 2 3 ( 浙江省立同德医院, 杭州310012; 浙江大学医学院, 杭州310058; 浙江大学医学院附属儿童医院, 杭州310003) 摘要 肌腱损伤是临床的常见病之一, 其愈合后易发生黏连而影响肌腱功能, 因此, 有效 地改善和促进愈合、恢复肌腱功能成为亟待解决的主要问题。为求在根源上找到解决问题的 方法, 众多学者对肌腱发育的机制进行了大量的研究, 发现了肌腱发育和分化的关键转录因子 Scleraxis(SCX)和Mohawk(MKX) 。为了更好地了解肌腱发育机制, 该文主要对转录因子SCX和 MKX 的发现、在肌腱中的分布和功能以及参与的信号通路等方面进行了阐述。 关键词 转录因子; SCX; MKX; FGFs信号通路; TGFβ信号通路 Transcription Factors SCX and MKX Research Progress in Tendon Development and Differentiation 1 2 3 2 3* Wu Zhen , Zhang Ziwang , Wang Xiaoai , Zheng Liling , Wu Fang 1 2 ( Tongde Hospital of Zhejiang Province, Hangzhou 310012, China; Zhejiang University School of Medicine, Hangzhou 310058, China ; 3The Children’s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China) Abstract Tendon injury is one of common clinical diseases. It is very easily to do harm to tendon function due to the adhesion. Thus, the effective improvement and promotion of healing and recovering of tendon function become main problems to be solved. In order to find the methods to solve the problem at the source, many scholars on tendon development mechanism carried out a large amount of research, finding that the key transcription factors of tendon development and differentiation are SCX (Scleraxis