progress in study on reactive oxygen species and - 临床与病理杂志.pdf

临床与病理杂志 2014, 34(2) 182 J Clin Path ol R e s DOI:10.11714/j.issn.2095-6959.2014.02.012 /gjblkx/fileup/PDF/201402182.pdf 活性氧与肾纤维化的研究进展 1 2 覃娇 ，陶立坚 综述 (1. 长沙市中心医院肾内科，长沙 410004；2. 中南大学湘雅医院肾内科，长沙 410008) [摘　要] 肾纤维化是各种慢性肾疾病进行性发展的主要病理基础，活性氧在肾纤维化的发生和发展中扮演 - 着重要的角色。有关抗氧化治疗肾纤维化的研究较多，N 乙酰半胱氨酸、血管紧张素转换酶抑制 剂、氟非尼酮、维生素E等被认为有一定的肾保护作用，这也为肾纤维化的临床防治提供新的研究 方向和治疗靶点。 [关键词] 活性氧；肾纤维化；NDAPH氧化酶 Progress in study on reactive oxygen species and renal fibrosis QIN Jiao, TAO Lijian (1. Department of Nephrology, Changsha Central Hospital, Changsha 410004; 2. Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China) Abstract Renal fibrosis is a major histological feature in many chronic kidney diseases. More and more studies have demonstrated that reactive oxygen species play significant role in the development of renal fibrosis. The therapeutical effect of drugs with antioxidative activities on renal fibrosis is well studied. N-acetylcysteine, angiotensin-converting enzyme inhibitors, fluorofenidone and vitamin E are able to protect kidney, at least partially, from fibrosis, which may provide novel thoughts for therapeutic targets of renal fibrosis. Key words reactive oxygen species; renal fibrosis; nicotinamide adenine dinucleot