Measuring-tumor-cell-proliferation-with-18F-FLT-PET-during-radiotherapy-of-esophageal-cancer课件.pptxVIP

Measuring tumor cell proliferation with 18F-FLT PET during radiotherapy ofesophageal squamous cell carcinoma:A pilot clinical study;Patients;制药;显像;Timing of Scans扫描时间;;结果--Patient characteristics are summarized in Table 1.;;;On-Treatment 18F-FLT PET/CT: Tumor Repopulation;FIGURE 2. Tumoral SUVmax on 18F-FLT PET at different TDs;FIGURE 3. Proliferation target volume (pTV) on 18F-FLT PET at different TDs.;A. 放疗前，SUV最大值1.2；增殖靶区0；B.30Gy/15次，SUV最大值1.1；增殖靶区0；C.50Gy/25次，SUV最大值1.2；增殖靶区0；;;Patient 19 ：2-Gy 治疗2d后停止； 肿瘤的 SUVmax and增殖靶区超过基线；而受照后的骨髓放射性摄取下降 A.放疗前，肿瘤的 SUVmax：7.02 and增殖靶区:23.8cm3； B.TD of 2Gy/1次、治疗停止；肿瘤的 SUVmax：8.22 and增殖靶区:27.9cm3； 放射野包括：椎体左半部分；蓝线为入射线方向；受照后骨髓FLT摄取下降;On-Treatment 18F-FLT PET/CT: Lymph NodeMetastasis Repopulation;On-Treatment 18F-FLT PET/CT: Normal-Tissue Response;18F-FLT PET and 18F-FDG PET: Inflammation and Tumor;A 治疗后FDG在原发灶中浓聚； B 相应FLT为缺损； C一月后FLT放射性仍缺损； D FDG SUVmax 9.5； E 延迟显像SUVmax 7.7； F 病理显示为验证;讨论;;;;;;