超声微泡对大鼠前列腺中药物浓度的影响-第三军医大学学报.DOC

超声微泡对大鼠前列腺中药物浓度的影响-第三军医大学学报.DOC

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超声微泡对大鼠前列腺中药物浓度的影响-第三军医大学学报

低剂量超声联合微泡造影剂对大鼠前列腺组织伊文思蓝浓度的影响 易善红,陈伟,刘永亮,刘政,叶钢 中国人民解放军第三军医大学附属新桥医院泌尿外科,重庆市,400037 【摘要】 目的:采用低剂量超声辐照联合微泡造影剂,提高前列腺内的药物浓度。方法:选取SD大鼠50只,随机分为对照组,伊文思蓝组、微泡组、联合即刻组以及联合延迟组。全部组别均给予相同剂量的超声辐照5min,对照组给予生理盐水,伊文思蓝组以50mg/kg剂量给于伊文思蓝,微泡组以1ml/kg剂量给于微泡造影剂,联合即刻组尾静脉注射伊文思蓝及微泡后并用超声治疗仪前列腺局部间歇辐照5 min,联合延迟组尾静脉注射微泡后并用超声治疗仪前列腺局部间歇辐照5 min,其后30分钟再给予EB。实验结束后取前列腺组织病理观察,并行前列腺组织匀浆测量伊文思蓝的浓度变化。结果:对照组前列腺组织中没有药物,EB组前列腺组织中药物浓度较对照组高(P0.01),联合即刻组前列腺组织中药物浓度较EB组以及延迟组高(P0.05)。结论:低剂量超声联合微泡造影剂可明显提高前列腺组织药物浓度,且有一定的时相性。 【关键词】药物浓度;大鼠;超声;微泡;前列腺;EB Experimental study on the influence of low-dose ultrasound-mediated microbubble on the EB concentration in the rat prostate 【Abstract】Objective: To increase the medicine concentration in rat prostate through low-dose ultrasound Mediated Microbubble. Methods: 60 male Sprague- Dawley rats were castrated and divided into five groups randomly,contrast group,EB(Evans blue, EB) group, microbubble group, union treatment instant group and union treatment delay group. All groups were given low-dose ultrasound five minuets , contrast group was treated with sodium chloride,EB group were given with EB lonely, microbubble group were given with microbubble, union treatment instant and delay groups was given low-dose ultrasound-mediated microbubble and EB. Concentration of EB in prostate was measured after the prostate was taken and homogenated. Results: Concentration of EB in union treatment group as higher than that of in contrast group(P0.01).But more EB was measured in ultrasound-mediated microbubble instant group than in EB group and union treatment delay group(P0.05). Conclusion: Low-dose ultrasound-mediated microbubble can markedly promote the increase in the drug concentration in rat prostate, and the effect was related with times. 【Keywords】Medicine concentration;Rat;Ultrasound;Microbubble;Prostate;EB 前列腺炎是我国发病率较高的男性生殖系统感染性疾病之一,占泌尿外科男性门诊患者的25%-30%,近年来发病率呈上升趋势[1]。临床对于前列腺炎的治疗以药物治疗为主,但是由于血-前列腺屏障的存在,目前常规的药物治疗较难在前列腺内形成有效治疗浓度,从而影响其临床治疗效果[2]。如何增加前列腺组织的通透性,在前列腺组织内达到有效的药物浓度一直是慢性前列腺炎治疗研究的

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