老年慢性肝病患者血清鸟嘌呤脱氨酶,胆碱脂酶变化与临床意义.docVIP

【摘要】 目的 探讨老年慢性肝病患者鸟嘌呤脱氨酶（GD）和胆碱脂酶（CHE）的变化及临床意义。方法 对80例老年慢性肝病患者及100例健康老人血清中GD和CHE活性进行检测。结果 老年慢性肝病患者血清中GD活性明显高于正常对照组,且随病情加重而升高更为明显（P＜001）；血清CHE活性明显低于正常对照组，且随病情加重降低更为明显（P＜001）；GD与CHE呈负相关（P＜005）。结论 GD和CHE是反映肝实质细胞受损害及其合成代谢能力下降的敏感指标。联合检测GD、CHE的变化可以反映肝病发展的程度，对了解病情，判定治疗效果及预后有重要意义。 【关键词】 慢性肝病 鸟嘌呤脱氨酶 胆碱脂酶 　　The changes in serum guanine deaminase and cholinesterase of aged patients with chronic liver diseases and their clinical significance 　　WANG LiQiang, SUN XiaoLing, XU WenLiang, et al 　　The First Clinical Hospital of Jilin University, Changchun 130021, Jilin, 　　【Abstract】 Objective To investigate the changes and clinical significance of serum guanine deaminase (GD) and cholinesterase (CHE) of aged patients with chronic liver diseases.Methods The serum GD and CHE activities of 80 aged patients with chronic liver diseases and 100 normal cases as control were determined.Results The activities of serum GD and CHE of aged patients with chronic liver diseases were significantly higher and lower respectively than those of control group (P＜0.01), and the changes were much obvious with the aggravation of illness. Both of GD and CHE were negatively correlated（P＜0.05）.Conclusions GD and CHE could be the sensitive markers of reflecting the damage and synthetic metabolism of liver cell. It was important to detect the GD and CHE for judging the degree of chronic liver diseases, therapeutic effect and prognosis. 　　【Key words】 Chronic liver diseases; Guanine deaminase (GD); Cholinesterase (CHE) 　　血清鸟嘌呤脱氨酶(guanine deaminase，GD)应用于肝病的研究在国外已有报道〔1〕,但在国内,特别是老年慢性肝病的研究尚未见报道。本文旨在探讨老年慢性肝病患者血清GD活性变化及其与胆碱酯酶（CHE）活性的相关性及临床意义。 　　1 材料与方法 　　11 对象 正常对照组100例，为健康体检者，年龄60～72岁，平均632岁；慢性肝病组80例,为本院2003年6月～2005年6月住院及门诊患者,男34例,女46例,年龄61～72岁,平均622岁,其中慢性迁延性肝炎42例,肝硬化23例，原发性肝癌15例,诊断依据参照1990年全国肝炎会议标准。 　　12 方法 受检者均于就诊当日静脉采血,当日测定完毕。GD和CHE试剂盒由吉林省惠强生物技术有限公司提供，方法与说明书一致，仪器为日立-7600型全自动生化分析仪。 　　13 统计学处理 实验结果以x±s表示,两均数比较采用t检验;GD与CHE之间的相关性为直线相关分析。 　　2 结果 　　老年慢性肝病患者中，肝硬化组及慢性迁延性肝炎组血清CHE活性明显低于正常