多囊卵巢综合征临床特征分析.pdfVIP

Journal of Medical Forum Vo1．29 No．5 March 20o8 · 27· 多囊卵巢综合征临床特征分析 周 焰 ，秦贵军 郑州大学第一附属医院内分泌科 郑州市 450052 摘要 目的 分析总结多囊卵巢综合征(PCOS)患者的临床及内分泌代谢特征。方法 选择38例肥胖 型PCOS及非肥胖型40例比较黄体生成索(LH)、卵泡刺激素(FSH)、睾酮(T)、空腹胰岛素(FINS)、空腹血糖 (FBG)。用稳态模型指数(HOMA—IR)、胰岛索曲线下面积(IAUC)评估胰岛素敏感性。结果 两组患者睾酮 水平无明显差别。非肥胖组LH、LH／FSH比值高于肥胖组；两组胰岛素抵抗(IR)发生率分别为76．3％及 15．0％，肥胖组FINS，HOMA IR，GAUC和IAUC均高于非肥胖组。结论 肥胖组较非肥胖组存在更严重的内分 泌及代谢紊乱，其远期并发症的防治应受到高度重视。 关键词 多囊卵巢综合征；胰岛素抵抗；肥胖 中图分类号：R711．75 文献标识码：B 文章编号：1672—3422(2008)05-0027-02 Clinical Analysis of Obese Women with Polycystic Ovary Syndrome ZHOU Yan，Qm Cu~,n Department ofEndocrinology，The First Affdiated Hospital ofZhenzhou Unive~ity，Zhengzhou 450052，China ABSTRACT Objective To observe and analyze the clinical presentation，hormonal profile， and metabolic abnormalities of obese women with polycystic ovarian syndrome(PCOS)．Methods T0一 tal 78 cases PCOS patients were divided into obese and non—obese groups according to the body mass index(BMI)．The data of the clinical manifestation of hyperandrogenism。serum levels of Gonadotro— phin，testosterone(T)，fasting insulin(FINS)，fasting blood~ucose(FBG)，homeostasis model asseSS— ment(H0MA)and area under curve(IAUC)were examined and compared for all patients．Remtlts Total 38 cases(48．7％)PCOS were obesity of which 30 cases(78．9％)were central obesity．The prevalence of IR was 44．9％with a higher prevalence rate in group A(76．3％)compared with that in group B(15．0％)． e values of FINS，HOMA IR，GAUC and认UC were all higher in group A than that in group B．Conclusion Obese PCOS patients have more severe IR and hyperinsulinism than that of non—obese PCOS women．which may have some health implications later in life． KEY