前列地尔对急性心肌梗死患者血管活性物质影响的观察.pdfVIP

现代医药卫生2008年24卷第6期 前列地尔对急性心肌梗死患者血管活性物质影响的观察 王 翠 。刘学辉 (1．盘锦市第一人民医院，辽宁盘锦124010；2．北镇市第二人民医院，辽宁北镇121308) 【摘要】目的：探讨前列地尔在治疗急性心肌梗死(AMY)rPXC~t管活性物质及凝血功能影响的作用及机制。方法：57例AMI患者随 机分为前列地尔(治疗组)和常规对照组。两组患者均接受常规标准治疗，治疗组加用前列地尔注射液10 ，每日1次静脉注射，连用 2周。于给药前和给药后取血检测患者的内皮素(ET)、一氧化氮(NO)、血栓素B：(Tx B：)、纤维蛋白原(FIB)等指标。结果：治疗14天 后两组比较，治疗组ET、TX B2、FIB均有明显降低，NO明显上升，P0．05。结论：前列地尔有明显降低冠状动脉张力，减少血小板聚 集．抑制血栓形成的作用。 【关键词】前列地尔；急性心肌梗死；血管活性物质 文章编号：1009—5519(2008)06-0822-o2 中圈分类号jR5 文献标识码：A Clinical observation on vesselfactors effect ofliposomalprostagLandinElinmyocardialinfarction WANGCu (Thefirstpeople hospital ofPanjin city， ∞n 124010，China) 【Abstract]Objective：To investigate the vessel fac 时and COa{；ulation function effect and its mechanism of liposemal pro~ din El po PG E1)in patients with myocardial infarction(AMY)．Methods：57 patients were randomlyvMed into PG El group or iDu- tine treatment control group．All patients received the sanle standard ctreatment．The patients in Lipo PG E1 group received Lipo PG El 10 g，d intravenous injection for 14 days．Blood concentration of Endothelin ，Nitric oxide(NO)，thromboxane Bz(TXB2)，fibrinogen B) were meagul~ at baseline and after 14 days of therapy．Results：After 14 days treatment，except NO risen，all of ET，TXB2 and FIB are decreased significant compared with those in the control group(all PO．o5)．Conclusion：Lipo PGE,Can reduce significantly strain of COrO- nary artery，decrease platelet conglomeration and restrain thrombus in patients with acute myocardial infarction． 【Key words]Liposoma]prostaOandin E1；Acute myocardial infarction；Vessel factor 急性心肌梗死(AM1)发生机制是在动脉粥样硬化的基础 处理，均数的比较用t检验，P0．05有统计学意义。 上。粥样斑块破裂、出血和血栓形成或冠状动脉痉挛，导致冠状 2 结果 动脉完全或不全