全身播散性卡介苗病多次合并机会性感染1 例附文献复习.pdf

458 2009 11 20 9 6 Chin J Infect Chemother, November1 2009, Vol1 9, No1 6 # # 1 陈晓红, 阮 琰, 林 伟, 严红梅, 陈国鸿, 刘坦业 : , , BECT EC 9 60 ,( SPOLIGOT YPING) PC (H37 V) (M . bov is) , , , ,, : ; : 186 .2 :A : 10 09-770 8( 20 09)0 6-0458-04 Recurrent opportunistic infecti ons secondary to systemic or disseminated BCG dis- ease: a case report and literature review CH EN X iao-hong , R UA N Yan, L I N Wei , YA N H ong-mei , CH E N Guo-hong , L I U T an-y e. D ep ar t- ment of T uber culosis , Fuz hou P ulmonary H osp ital, Cl inical T eaching H osp ital of Fuj ian Medical Uni- v er sity , Fuz hou 3500 08, China) Abstract: Objective To review the clinical features and etiology of the recurrent opportunistic infections following systemic or disseminated BCG disease to provide datafor future diagnosis and therapy. Methods A series of the clinical, laboratory and im- aging data of one patient with recurrent opportunistic infections following systemic or disseminated BCG disease were reviewed and analyzed together with relevant literature reports. Results The isolate was identified as M y cobacter ium tuber culos is var bo- vis by BECTEC 960 culture and specific identification technique. It was confirmed as a BCG strain via spoligotyping and PC assay to make alignment between the reference TB strain H37 V, M . bov is and BCG strain. The results of cellular and humor- al immunity assays suggested that the patient was at low level immunity. A number of therapeutic efforts did not result in ex- pected outcome. Conclusions Low-level immunity competence is one of the causes of recurrent opportunistic infectio