乌贝温中汤治疗虚寒型十二指肠溃疡的临床探究.pdfVIP

提 要 目的:观察乌贝温中汤治疗十二指肠溃疡（duodenal ulcer，DU），中医辨证为虚 寒型的临床疗效，并从理论和临床研究两个方面探讨乌贝温中汤治疗虚寒型 DU 的机 制。 方法:临床选择符合纳入标准的DU患者60例，随机分为两组，试验组(30例)给 予乌贝温中汤，对照组(30 例)给予虚寒胃痛颗粒，两组均以 4 周为一疗程，连服 2 个疗程。观察两组的临床疗效，并对治愈患者随访6个月，观察远期疗效。 结果:临床研究显示，试验组中医证候疗效、胃镜疗效及远期抗复发疗效等均优 于对照组(P0.05 或 P0.01)。试验组能明显改善空腹及夜间胃脘疼痛、脘腹痞满、 嗳气吞酸、纳呆食少等症状，其疗效优于对照组(P0.05 或 P0.01)。两组治疗期间 均未发生不良反应。 结论:乌贝温中汤是治疗虚寒型DU的有效方剂，其机理可能与抑酸、杀灭幽门螺 杆菌(Hp)、调节机体免疫、增强粘膜屏障功能等有关。 关键词 乌贝温中汤；十二指肠溃疡；虚寒型；临床研究 1 Clinical study of the Wu Bei Wen Zhong Tang (WBWZT) Treated Deficiency duodenal ulcer Speciality:Internal Medicine of Traditional Chinese Medicine Author ：Shao Zhongying Tutor：Prof.Wang Weiming Abstract Objective:To observe the effect of Wubeiwenzhongtang (WBWZT) on Duodenal Ulcer(DU) and explore the mechanism of it. Method: 60 Patients with DU were divided into two groups at random: the treatment group and the control group.The treatment group was given WBWZT，and the control group was given Xuhanweitongkeli(XHWTKL) 4 weeks were set as a course of treatment and even served 2 courses. The clinieal effects of each group were observed during the course and the follow-up survey of 6 months. Results:The effective of syndrome of TCM、enteroscopy observing of the treatment group are better than that of the control group are better than that of the control group(P0.01 or P0.05).WBWZT can improve more signifieantly the symptoms such as stomachache、 abdominal distention 、 belehing and acid regurgitation and anorexia than XHWTKL(P0.01orP0.05). Conclusions: WBWZT appears to have the significant effect in the treatment of DU. The mechanism of this therapy maybe relation to relieving hyperaeid