健脾疏肝饮治疗糖尿病胃轻瘫的疗效视察.pdfVIP

提 要 目的：通过临床病例观察和动物实验研究健脾疏肝饮治疗糖尿病胃轻瘫 （Diabetic Gastro Paresis.DGP ）的疗效。方法：1.临床观察：将 60 例 DGP 患者随机 分为试验组与对照组各 30 例。在基础治疗前提下，试验组给予疏肝健脾饮汤剂（基 本方为：柴胡，白芍，枳实，党参，黄芪，白术，姜半夏，黄连，生姜，厚朴，木 香，当归，炙甘草。）口服；对照组予吗丁啉口服。以临床症状积分、空腹和餐后 2h 血糖以及糖化血红蛋白等为评价标准，通过与对照组的比较讨论疗效。2.动物实 验：建立糖尿病胃轻瘫大鼠动物模型，给予中药或生理盐水灌胃 8 周后，通过模型 组，中药组和正常组的阳性神经免疫组化染色比较，讨论健脾疏肝饮的疗效。结 果：1.临床观察：治疗组总有效率为 93.3%，对照组总有效率为 76.7% 。两组在治疗 后症状总积分上有显著差异(P0.01)，单独症状积分比较显示：两组在治疗早饱、胃 脘胀满、嘈杂、纳呆的疗效相当 (P0.05) 。而治疗组对 DGP 患者嗳气、倦怠乏力、 恶心、情志不舒等的疗效较对照组有优势(P0.05) 。2.动物实验：8 周后大鼠胃窦肌 间神经丛中 nNOS 、5-HT R 染色阳性神经平均灰度值，中药组与模型组、熟地组有 4 显著差异 (P0.01) ；而它们与正常组比较无明显差异(P 0.05) ；表明健脾疏肝饮可对 糖尿病大鼠胃窦肌间神经丛有保护作用。结论：疏肝健脾饮在治疗糖尿病胃轻瘫方 面有良好的疗效，有临床应用前景。 关键词 糖尿病胃轻瘫 疏肝健脾 临床/动物实验观察 Study on Jian Pi Shu Gan Yin in Treating Diabetic Gastro Paresis Speciality：Medicine of TCM Author ：CaiKan Tutor：Prof.ZhangJuan Abstract Objective ：To observe the therapeutic effect of traditional Chinese medicine on diabetic gastroparesis 。 Methods ： Clinical research ： 60 patients with diabetic grastroparesis were randomly divided into two groups.30 patients in experimental group were treated by traditional Chinese medicine ；30 patients in control group were treated by single western medicine ，with a treatment course of eight weeks for both groups.The therapeutic effects were evaluated after 1 treatment course.Animal Experiment:building animal models of diabetic gastro paresis,to abserve difference of nNOS 、5-HT R between 4 the Normal group and treated group.Results ：Clinical research ：There was a significant difference in improvement of symptoms,and in the aspect of nausea anorexia eructation and epigastric upset.Animal E