加味乌梅汤治疗寒热错杂型功能性腹泻的临床探究.pdfVIP

提 要 目的：观察加味乌梅汤治疗寒热错杂型功能性腹泻的临床疗效，并进一步探讨其 治疗功能性腹泻的作用机理。 方法：临床选择符合纳入标准的功能性腹泻患者60例，随机分为治疗组（30例） 和对照组（30例），治疗组予以自拟加味乌梅汤加减治疗，对照组予以固肠止泻丸， 两周一疗程，治疗两疗程。治疗结束后进行临床症状、中医证候等疗效性观察。 结果：临床研究显示，在临床症状疗效方面，治疗组在消除或改善粪便性质、减 轻排便频次，改善全身症状上，疗效优于对照组（P0.05）；治疗组在中医证候疗效 方面，治疗组治愈15例，显效10例，有效3例，痊愈+显效率为83.33%，总有效率 为93.33%；对照组临床痊愈9例，显效8例，有效4例，痊愈+显效率为56.67%，总 有效率为 70.00%；治疗组显著优于对照组（痊愈+显效率及总有效率皆 P0.05）；治 疗组在中医症状总积分改善方面，疗效优于对照组（P0.05）。治疗组疗程结束时， 血、尿、大便常规及心、肝、肾功能等检测均未发生不良反应。 结论:加味乌梅汤是治疗寒热错杂型功能性腹泻的有效方药，其机理可能与调节 胃肠运动及胃肠激素的水平，抗炎、调节免疫功能，修复肠道微生态平衡等有关。 关键词 功能性腹泻；寒热错杂；加味乌梅汤；临床研究 Clinical Study of JiaWeiWuMeiTang in Treating Functional Diarrhea with The cold-heat jumble Syndrome Specialty : Internal Medicine of TCM Author: Ma Weiwei Tutor: Professor Liu Dongmei Abstract Objective: To assess the efficacy and mechanism of JiaWeiWuMeiTang in the treatment of Fd with The cold-heat jumble syndrome. Methods: 60 patients were devided randomly into two groups.30 patinets were received JiaWeiWeiMeiTang as the study group,and 30 patinets were received GuChangZhiXie capsules as the control group. After 4 weeks treatment,the changes of clinic symptom were analyzed. Results: In the efficacy of TCM，the treatment group was better than control group (p0.05). After one course of treatment,significant difference was apparent in the clinical effects:In the treatment group，15 cases recovered and 10 cases significantly improved， (thus the effectual rate is 83.33%),3 cases improved. The total effective rate in the treatment group is 93.33%. In the control group ，9 cases recovered and 8 cases significantly improved，(thus the effe