动脉硬化闭塞症炎症细胞因子的变化规律及中医证型的相关性研究.pdfVIP

提 要 目的：本课题通过炎性细胞因子水平变化与动脉硬化闭塞症中医辨证分型关系的 研究，进一步探讨动脉硬化闭塞症的病理机制。方法：筛选动脉硬化闭塞症患者 60 例及健康对照组 30 例作为研究对象，根据中医证型分为血瘀型和湿热下注型各 30 例，收集研究对象的一般资料并检测超敏C反应蛋白、肿瘤坏死因子-α、白介素-6、 白介素-10等客观指标，分析比较各型之间及与对照组之间的微观炎症指标变化。结 果：研究显示 ASO 患者的促炎症细胞因子 Hs-CRP、TNF-α、IL-6 均升高，与对照组 比较具有非常显著的差异性(P0.01)，其中湿热下注型促炎症细胞因子水平明显高于 血瘀型，差异有显著性(P0.05，P0.01)；而IL-10水平在血瘀型、湿热下注型和对 照组之间并无明显差异。结论：动脉硬化闭塞症中医各证型均存在 Hs-CRP、TNF-α 及 IL-6 增高现象，并在不同证型中存在差异，同时促炎因子与抗炎因子平衡也影响 了ASO的病情变化，支持炎症细胞因子参与ASO发生与发展的整个病理过程的理论， 并可作为中医临床辩证的客观指标之一。 关键词 动脉硬化闭塞症；炎症；细胞因子；中医证型；临床研究 Research on the Significance of Changes of Inflammatory cells in Traditional Chinese Medicine Syndromes of Arteriosclerosis Obliterans Specialty: Peripheral Vascular Diseases , Surgery of TCM Author: Tan Jian-feng Tutor: Prof. Hou Yu-fen Abstract Objective: To present the subject through the inflammatory cytokines levels and atherosclerosis obliterans syndrome differentiation relations research, to further explore arteriosclerosis obliterans pathogenesis. Methods: Screening of patients with arteriosclerosis obliterans in 60 cases and 30 cases of healthy control group for the study, according to TCM syndrome is divided into blood stasis and pathogenic dampness-heat type of the 30 cases, collect general information on research subjects and to detect high-sensitivity C reaction protein, tumor necrosis factor-α, IL -6, IL-10, analysis and comparison between various types and with the control group between the indicators of changes in micro-inflammation. Results: The study showed patients with ASOs pro-inflamma