可分解的奈米载体对于药物安定性及控制释放的应用交通大学材料 .pdf

奈 Stabilization and Controlled Release of Active Agents via a Degrading Nano-Carrier 料 : 年六 1 奈 奈 兩 奈料來奈 理行 料 數聯度 粒例數 量度度 量數 數 度 料良 量降 數 不不易 力奈來參 ABSTRACT The object of this study was to manipulate the drug permeability and stability of nano Ca-deficient hydroxyapatite/Chitosan (CDHA/CS) nanocomposite membrane incorporated with vitamins for drug storage and controlled release. The physical properties and drug permeation behaviors of Ca-deficient hydroxyapatite/Chitosan (CDHA/CS) nanocomposite membrane were systematically investigated in terms of different synthetic sequence and inorganic filler amount. It was found that the lowest permeation coefficient was obtained via in-situ process (P-CS-Ca), which was probably due to the higher crosslinking extent, better interface between filler and matrix, and smaller particle size, as well as dispersion. With an increase of CDHA content, both crosslinking and diffusion path would be increased so that the permeation coefficient of CDHA/CS composite membrane was reduced compared to that of pure chitosan membrane. A minimum permeation coefficient occurs at the CDHA content of 90%. In this condition, the drug can be safely stored for a long time. 2 料 了 例: 療… 料不連 料不奈料 不力 烈 C見 C 療 了便C 來療 了 療 奈 量 度 料 類 料 料料