大黄蟅虫丸抗肝肿瘤机理探究.pdfVIP

提 要 目的：通过理论和实验研究，探讨肝肿瘤发病的病因、病机、治疗思想以及大 黄蟅虫丸抗肝肿瘤的作用机理。方法：理论研究方面，结合古代文献和现代研究阐述 血瘀与癌毒是肝肿瘤发生的主要因素，同时也是病机的主要组成部分，治疗上主张祛 邪为主，不能妄加扶正；实验研究方面，建立荷肝癌(H22)小鼠模型，观察大黄蟅虫丸 药液对其肿瘤生长的影响；对小鼠生存期的影响以及含药血清组对鸡胚尿囊膜血管生 成的影响。结果：大黄蟅虫丸可以改善荷瘤小鼠生存质量，稳定并提高体重，大、小 剂量组肿瘤重量与对照组相比均有显著差异（p0.01 ）；大黄蟅虫丸组肝癌(H22)小鼠 生存期明显延长（p0.01 ）；大黄蟅虫丸血清组对生长5～7 d 的鸡胚血管数有抑制作用。 结论：大黄蟅虫丸能有效抑制肿瘤生长，提高生存质量；延长生存期；服用大黄蟅虫 丸的大鼠血清对鸡胚血管有明显的抑制作用，提示大黄蟅虫丸可能通过抑制血管新生 从而起到抗肝肿瘤的作用。 关键字 大黄蟅虫丸；肝肿瘤；机理研究 The Mechanism Study of Dahuangzhechong Bolus on liver cancer Speciality：TCM clinic basis-Jin kui yao lve Author ： Song Rongqiang Tutor： Lv Cuixia Abstract Objective: To observe the Etiology and Pathogenesis and treatment of liver cancer and the mechanism of Dahuangzhechong Bolus on liver tumor through theory and experimental study.Methods: In the respect of theory:Elaborate Blood stasis and Cancer toxic is the main factors of Liver cancer Etiology and Pathogenesis with Ancient literature and Modern research. So Treatment should based on the idea Quxie not make improper righting. In the respect of experimental study:To Observed the effect of Dahuangzhechong Bolus about tumor growth of H22 tumor-bearing mice and the angiogenesis on chick embryo chorioallantoic membrane in the role of Dahuangzhechong Bolus Serum. Result: Dahuangzhechong Bolus can improve the quality of life, stabilize or enhance body weight , the big dosage group and the little dosage compare with the control group have distinct difference on the carcinoma weight (P0.01), Dahuangzhechong Bolus Serum can inhibited the number of blood vessels of 5-7d Chorioallantoic membrane. Conclusion: Dahuangzhechong Bolus can inhibit the growth of liver