天灵再造液治疗脑梗死恢复期临床和实验研究.pdfVIP

提 要 目的：研究天灵再造液治疗脑梗死恢复期的疗效和作用机理，并进一步探讨补肾 活血化痰通络法在脑梗死恢复期治疗中的地位。方法：临床研究观察脑梗死恢复期病 人共计 60 例，随机分为天灵再造液治疗组和维脑路通片对照组各 30 例，28 天为一 疗程。治疗前后进行神经功能评分和中医证候评分，并比较血脂、凝血四项、血流变 及各项安全性指标的变化。动物实验采用血管内拴线阻断法阻断右侧大脑中动脉制备 大鼠脑缺血模型。检测各组动物血清和脑组织匀浆的丙二醛（MDA）含量和超氧化物 歧化酶（SOD）活力及对大鼠全血粘度、血浆粘度、血小板聚集率的影响。结果：临 床研究结果治疗组临床功能和中医证候总有效率分别为 90%和 93.3%，明显优于对照 组的 76.7%和 70%（P0.O5）。动物实验结果表明，天灵再造液可以降低脑和血清中 MDA的含量，提高SOD的活力，降低血粘度及血小板聚集率。结论：临床观察显示天 灵再造液治疗脑梗死恢复期疗效较为满意，能有效改善神经功能缺损、血液流变学指 标、凝血指标。动物实验证实天灵再造液可以减轻脑缺血后的自由基损伤，减轻局部 的炎症反应，减轻迟发性神经元坏死，保存神经功能。 关键词 天灵再造液 脑梗死恢复期 临床研究 实验研究 Clinical and Experimentcal Research on Treatinge convalescence stage of cerebral infarction With TianLingZaiZao decoction Speciality： Internal Medicine of TCM Author ： Qiu Juanjuan Tutor： Pro. Hu-Zhiqiang Abstract Objective： To study the efficacy and mechanism of TianLingZaiZao decoction and discover the importance of nourishing kidney, purging phlegm, promoting blood circulation in Treatinge convalescence stage of cerebral infarction. Methods ：We observed 60 cases in clinical study of cerebral infarction. They were randomly divided into the treatment group of TianLingZaiZao decoction and the control group of Weinaolutong, and each had 30 cases for 28 days for a course of treatment. Before and after treatment, we scored nerve function and syndromes of TCM, and compared blood lipids, four indicators coagulation, variable flow and the security indicators and found the changes. In the animal experiments, we blocked the right middle cerebral artery and made the rat model of cerebral ischemia by intravascular thread-tying blocking method. The animals were detected in serum and brain tissue of malondialdehyde （MDA ）content and superoxide dismutase （SOD ） activity in ra