羟基脲组成联合化疗方案治疗高细胞急性白血病疗效观察.docVIP

羟基脲组成联合化疗方案治疗高细胞急性白血病疗效观察【摘要】 目的 探讨羟基脲组成联合化疗方案治疗高细胞急性白血病的疗效和并发症发生情况。方法 38例高细胞急性白血病分成二组,22例用羟基脲组成联合化疗方案来治疗,作为治疗观察组,16例只用联合化疗方案治疗,作为对照组,同时对二组之间的缓解率和发生的并发症等情况进行对比分析。结果 22例治疗观察组中,CR11例,PR 5例,NR 4例,死亡2例。16例对照组中,CR6例,PR3例,NR4例,死亡3例。治疗组和对照组之间比较,均无显著性差异,P0.05。治疗组化疗后外周血白细胞降至10×10?9/L以下,所需时间为(4.63±1.16)d,对照组为(6.55±1.97)d,二组之间比较,有显著性差异,P0.01。结论 高细胞急性白血病患者在急性白血病标准化疗方案基础上,加用羟基脲治疗,能够快而持久的抑制白血病细胞,可以降低患者颅内出血和ARDS的发生,对提高高细胞急性白血病的疗效,改善高细胞急性白血病的预后,延长高细胞急性白血病患者的生存期具有重要临床价值。 【关键词】高细胞;急性白血病;羟基脲;化疗 Treatment,s study of hypercellular acute leukemia with HU based combination regimen YU Yong wei,ZHOU Run qi,Shang guanhui,Zhang xiaoqing,et al.Hematological Department of the Second People’s Hospital,Foshan 528000,China 【Abstract】 Objective To observe the effect of HU based combination regimen in the treatment and complication of patients with hypercellular acute leukemia.Methods 38 patients with hypercellular acute leukemia were divided into two groups,22 patients with hypercellular acute leukemia were treated by HU in combination regimen,16 patients with hypercellular acute leukemia were treated dy combination regimen.Results The complete remissionof 22 patients in treatmented groupwas 11 cases,the partial remissionwas 5 cases,non remission of was 4 cases,2 patients were deathed.The complete remissionof 16 patients in controlled was 6 cases,PRwas 3 cases,NR was 4 cases,3 patients were deathed.the curative effect of the hypercell acute leukemia patients in betneen two groups Were the same,P0.05.The time of periphery blood white cell in chemotherapy was reduced under 10×10?9/L,the treatmented group was 4.63±1.16 days,the control group was 6.55±1.97 days,there was a significant difference between these two groups,P 1.3 疗效的评价 急性白血病的疗效观察则按照全国急性白血病的疗效标准[1]进行评价,用t检验或卡方检验对资料进行统计学的处理。 2 结果 2.1 治疗的效果 在全部高细胞急性白血病中,急淋患者12例,急非淋患者26例;急淋完全缓解(CR)9例,CR率为(9/12例)75%,部分缓解(PR)1例,PR率为(1/12例)8.3%,未缓解(NR)1例,NR率为(1/12例)8.3%,死亡1例。急非淋患者CR9例,CR率为(9/26例)34.6%,PR8例,PR率为(8/26例)30.8%,NR5例,NR率为(5