起薄液基细腔技术检查绝经后妇女宫颈ASCUS特点.docVIP

起薄液基细腔技术检查绝经后妇女宫颈ASCUS特点【摘要】 目的 分析绝经后妇女宫颈超薄液基细胞技术(AutoCyte PREP,Lct)检查结果中的未明确诊断意义的不典型鳞状细胞(ASCUS)的特点。方法 223例绝经后妇女Lct检查为ASCUS,结果与未绝经妇女ASCUS者相比较。全部患者均于对症治疗或观察3~6个月后复查Lct。结果 绝经后妇女ASCUS的发病率为19.31%(223/1155),未绝经者的发病率为4.9%(372/7595),两组间发病率的差异有显著性(P=0.003)。对绝经后妇女和未绝经妇女ASCUS者出现异常阴道镜像的行阴道镜下宫颈活检,两组间在慢性宫颈炎、CINⅡ和CIN Ⅲ发生率间的差异有显著性,CIN I及浸润癌发生率间的差异无显著性。绝经后ASCUS患者与未绝经者在对症治疗或观察3~6月后复查Lct,两组间持续为ASCUS发生率的差异无显著性(P=0.925)。结论 绝经后妇女自身的生理特点及慢性炎症是导致宫颈细胞学异常的因素。绝经后妇女ASCUS中严重的宫颈病变发病率虽较低,但仍存在不能忽视的宫颈病变。 【关键词】绝经;超薄液基细胞技术;ASCUS;宫颈 Characteristics of atypical squamous cells of undetermined significance by AutoCyte PREP test in postmenopausal women HUANAG Yong,YANG Hong.Department of Obstetrics and Gynecology,3rdHospital of Chengdu,Chengdu,Sichuan 610031,China 【Abstract】 Objective To investigate the characteristics of ASCUS by AutoCyte PREP test(Lct)in postmenopausal women.Methods Analysis was carried on 223 postmenopausal women with a Lct result of ASCUS.The results of the biopsy under colposcopy in 82 of them were compared with that of non menopausal women.All women with ASCUS were reexamined by Lct 3 6 months after treatment or observation.Results Postmenopausal andnon menopausal women with ASCUS who have ahnomal colposcopic results were received biopsy under colposcopy.The rate of abnormality had significant difference between two groups in chronic cervicitis(P=0.004),CIN Ⅱ(P=0.022)and CIN Ⅲ(P=0.037).The rate of abnormality had no significant difference between two groups in CIN Ⅰ(P=0.422)and SCC(P=0.301).There were 14.80%(33/223)of postmenopausal women remained to be ASCUS 3 6 months after treatment or observation,no significant difference compared with 14.52%(54/372)of non menopausal women(P=0.925).Conclusion The characteristics of ASCUS in postmenopausal women is that the rate of cervix diseases is low,but unneglectable cervix diseases still exists in them. 【Key words】 Postmenopausal; AutoCyte PREP test(Lct); ASCUS 超薄液基细胞技术(AutoCyte PREP,Lct)是近年来一种筛查及诊断宫颈病变的有效手段。本院对223例绝经后妇女L