清热利湿饮内服合消银洗药外洗治疗寻常型血热证银屑病的疗效视察.pdfVIP

提 要 目的：观察清热利湿饮内服合消银洗药外洗治疗寻常型血热证银屑病的临床疗 效；探讨消银洗药外洗对小鼠尾鳞片表皮颗粒层病理改变的影响，为中药内服加外洗 治疗银屑病研究提供初步的数据和资料。 方法：将63例寻常型血热证银屑病患者随机分成2组，Ⅰ组33例内服清热利湿 饮外用消银洗药，Ⅱ组30例内服清热利湿饮，2组疗程12周，临床观察各组药物的 疗效。实验部分利用小鼠尾鳞片因表皮正常角化缺乏颗粒层，模拟银屑病角化不全的 特点，设对照组及高、低浓度消银洗药组，电镜下观察药物对小鼠尾鳞片颗粒层病理 改变。应用统计学软件进行处理,为消银洗药外洗治疗银屑病研究提供初步的数据和 资料。 结果： Ⅰ组治疗寻常型血热证银屑病患者疗程结束的临床愈显率为 69.70%，总 有效率96.97%，Ⅱ组愈显率36.67%，总有效率80.00%。Ⅰ组临床疗效明显优于Ⅱ组， 二组相比有显著性差异。动物实验显示，消银洗药外用可促进小鼠尾鳞片表皮颗粒层 再生，提示其对银屑病具有治疗作用。 结论：清热利湿饮内服合消银洗药外洗治疗寻常型血热证银屑病疗效确切，复发 率低，其作用机理可能与抗病原微生物、抗炎、调节免疫、调节代谢障碍、抑制表皮 细胞增殖等有关。 关键词 寻常型银屑病；临床研究；动物实验；作用机理 The clinical curative effect observation for psoriasis vulgaris with Qing Re Li Shi Yin and Xiao Yin Xi Yao Specialty：Dermatology,Surgery of TCM Tutor ：Professor Du Xixian Author;Dong Xiuhui Abstract Objective: This study is to observe and contrast Qing Re Li Shi Yin and Xiao Yin Xi Yao’s effect on psoriasis vulgaris patients.To investigate Xiao Yin Xi Yao’s effect on Mouse tail scaled epidermis granular layer pathological changes,so as to provide initiatory data and information for the study of Xiao Yin Xi Yao ’s curative effect on psoriasis. Methods: The 63 psoriasis vulgaris patients are put into two groups at random.Group .Group Ⅰare given Qing Re Li Shi Yin and Xiao Yin Xi Yao( 33 patients), Group Ⅱ are given Qing Re Li Shi Yin only (30 patients),and the course of treatment is 12weeks, observate the curative effect of each group.The experiment using mouse tail scale due to lack of normal keratinized epidermis granular layer, simulate of psoriatic parakeratosis characteristics and sets up control group, and high concentration, low consumption of Xiao Yin Xi Yao. Observate drug