清热消癥方合化瘀止痛方分期治疗子宫腺肌病痛经的临床探究.pdfVIP

提 要 目的：观察清热消癥方合化瘀止痛方分期治疗瘀热蕴结型子宫腺肌病痛经的临床 疗效并探讨其作用机理。方法：共观察子宫腺肌病患者60例，治疗组30例，分期服 用清热消癥方与化瘀止痛方；对照组30例，分期服用散结镇痛胶囊和丹黄祛瘀胶囊， 观察两组患者痛经疗效及对 PGE 、ET-1、NO 及子宫体积的影响。结果：治疗后两组 2 患者痛经程度积分均较疗前明显降低（P0.01），治疗后组间比较有显著性差异 （P0.05），治疗组优于对照组。两组患者治疗后中医单项症状积分治疗组与对照组 相比有显著性差异（P0.05）；两组患者疗后 PGE 、ET-1、NO 含量较治疗前明显降 2 低，与治疗前相比均有非常显著性差异（P0.01），组间比较均有非常显著性差异 （ P0.01）；子宫体积治疗后较疗前明显缩小，与治疗前相比有非常显著性差异 （P0.01），与对照组比较有显著性差异（P0.05）。结论：清热消癥方与化瘀止痛 方分期治疗瘀热蕴结型子宫腺肌病痛经疗效较好，其机理可能与改善患者体内血液高 凝及血管内皮功能，减少炎性增生渗出及异位内膜的增生，调节经血前列腺素等多个 环节，从而使患者的痛经症状得到改善。 关键词 分期治疗；瘀热蕴结型；子宫腺肌病痛经；临床研究 The Clinical Research on the Effect of QingReXiaoZheng Fang and HuaYuZhiTong Fang in Treating Adenomyosis Dysmenorrhea Speciality: Gynecology of TCM, The study of menstruation sickness and sterility Tutor: Professor Ye Qing Author: Du Feng Abstract Objective：Observe the clinical curative effect of QingReXiaoZheng Fang combined with HuaYuZhiTong Fang, which is applied to treat adenomyosis dysmenorrhea, the stagnation-excessive heat type, and explore its work mechanism. Methods: We totally observed 60 patients of adenomyosis and it was divided into two groups randomly. The treatment group take QingReXiaoZheng Fang combined with HuaYuZhiTong Fang at stage, while the control group takes SanJieZhenTong capsule and DanHuangQuYu capsule at stage, which are compared to observe their curative effects and impacts on prostaglandin E2 、vascular endothelin-1 、Nitric oxide and Uterine volume. Results: After treatment,the dysmenorrhea level score of the two groups were obviously decreased (P0.01) and there were significant differences between groups (P0.05). Th